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PLK1-mediated PDHA1 phosphorylation drives mitochondrial dysfunction, mitophagy, and cancer progression in Cr(VI)-associated lung cancer

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110406Source: DataRank Database

PLK1-mediated PDHA1 phosphorylation drives mitochondrial dysfunction, mitophagy, and cancer progression in Cr(VI)-associated lung cancer is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Open Access5 citations

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Enrichment:Funding (9 grants)Impact (FWCI 3.02)OA: goldTopics (52)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (17)

Peng Jia ORCID,Zhiguo Li ORCID,Xiongjian Rao ORCID,Derek B. Allison ORCID,Qi Qiao ORCID

Live enrichment

PubMed:40544996 PMC:PMC12284512 OpenAlex:https://openalex.org/W4411474815

Markey Cancer Center, University of Kentucky

Grant: P30CA177558

National Institutes of Health

Grant: R01 CA272483

National Institutes of Health

Grant: R01 CA157429

National Institutes of Health

Grant: R01 CA256893

National Institutes of Health

Grant: R01 CA264652

National Institutes of Health

Grant: R01 CA196634

NIH National Institute of General Medical Sciences

Grant: P30 GM127211

National Institutes of Health

Grant: DoD-HT9425-24-1-0442

US Department of Defense

FWCI

3.02

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://www.jbc.org/action/showPdf?pii=S0021925825022562

publisherhttps://www.jbc.org/action/showPdf?pii=S0021925825022562

publisherhttps://api.elsevier.com/content/article/PII:S0021925825022562?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825022562?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2025.110406

Fields of Study

Trace Elements in HealthChromium effects and bioremediationFerroptosis and cancer prognosisMedicineEnvironmental ScienceProto-Oncogene ProteinsPolo-Like Kinase 1Protein Serine-Threonine KinasesMitophagyHumansCell Cycle ProteinsLung NeoplasmsMitochondriaChromiumAnimalsPhosphorylationMiceCell ProliferationDisease Progression

MeSH Terms

Polo-Like Kinase 1AnimalsChromiumHumansLung NeoplasmsMitochondriaPhosphorylationProto-Oncogene ProteinsProtein Serine-Threonine KinasesDisease ProgressionCell Cycle ProteinsCell ProliferationMiceMitophagy

Keywords

MitophagyCancerCancer researchPhosphorylationMitochondrionPLK1Lung cancerMedicineApoptosisInternal medicineChemistryBiologyCell biologyBiochemistryAutophagyCell cycleMitochondrial DysfunctionPolo-like Kinase 1 (Plk1)Hexavalent Chromium (Cr(vi))

Sustainable Development Goals

SDG 0: Good health and well-being

PLK1-mediated PDHA1 phosphorylation drives mitochondrial dysfunction, mitophagy, and cancer progression in Cr(VI)-associated lung cancer

FAIR Checklist

Authors (17)

Funding (9 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)