Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Genetic variants linked to neurodevelopmental disorders within the β3-β4 loop of the TRIO PH2 domain release autoinhibition of GEF2 activity

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110429Source: DataRank Database

Genetic variants linked to neurodevelopmental disorders within the β3-β4 loop of the TRIO PH2 domain release autoinhibition of GEF2 activity is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access2 citations

Download PDF

Cite:

Linked data & code

pdb

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 0.79)OA: goldTopics (40)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

Authors (3)

AndrewJ.M. Boulton,Anthony J. Koleske ORCID,Melissa G Carrizales

Live enrichment

PubMed:40581118 PMC:PMC12309612 OpenAlex:https://openalex.org/W4411682348

National Institutes of Health

Grant: R01MH133562

National Institutes of Health

Grant: F31NS131038

National Institutes of Health

Grant: R01MH132685

NIMH NIH HHS

Grant: R56 MH122449

National Institutes of Health

Grant: 5F31NS131038-02

Regulation of GluN2B-NMDA Receptors by Interactions with the Actin Cytoskeleton

National Institutes of Health

Grant: 1R01MH133562-01

Dysregulation of TRIO GEF1 activity in neurodevelopmental disorders

National Institutes of Health

Grant: 1R01MH132685-01A1

Identification and characterization of chemical probes of TRIO GEF1 activity

FWCI

0.79

Citation Percentile

0.7%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://www.jbc.org/action/showPdf?pii=S0021925825022793

publisherhttps://www.jbc.org/action/showPdf?pii=S0021925825022793

publisherhttps://api.elsevier.com/content/article/PII:S0021925825022793?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825022793?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2025.110429

Fields of Study

ATP Synthase and ATPases ResearchMacrophage Migration Inhibitory FactorPhosphodiesterase function and regulation0303 health sciences03 medical and health sciences

MeSH Terms

AnimalsHumansProtein Serine-Threonine KinasesGuanine Nucleotide Exchange FactorsrhoA GTP-Binding ProteinMiceHEK293 CellsRho Guanine Nucleotide Exchange FactorsNeurodevelopmental Disorders

Keywords

Domain (mathematical analysis)Loop (graph theory)GeneticsPsychologyComputational biologyBiologyMathematicsPH domainNeurodevelopmentGTPaseNeurite OutgrowthGuanine Nucleotide Exchange Factor (Gef)AutoinhibitionRas Homolog Gene FamilyMember A (Rhoa)Trio Family ProteinsMiceHEK293 CellsNeurodevelopmental DisordersHumansGuanine Nucleotide Exchange FactorsAnimalsProtein Serine-Threonine KinasesrhoA GTP-Binding ProteinRho Guanine Nucleotide Exchange FactorsResearch Article

Sustainable Development Goals

SDG 0: Zero hunger

Genetic variants linked to neurodevelopmental disorders within the β3-β4 loop of the TRIO PH2 domain release autoinhibition of GEF2 activity

FAIR Checklist

Authors (3)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)