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Two distinct protein-protein interfaces drive cooperative binding of the herpes simplex virus protein ICP8 to ssDNA, filament formation and annealing essential for viral replication

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110498Source: DataRank Database

Two distinct protein-protein interfaces drive cooperative binding of the herpes simplex virus protein ICP8 to ssDNA, filament formation and annealing essential for viral replication is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (5 grants)Impact (FWCI 1.45)OA: goldTopics (37)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

J. Krucinska ORCID,Renata Szczepaniak,Heidi Erlandsen ORCID,Andrea M. Makkay ORCID,Lee R Wright

Live enrichment

PubMed:40684942 PMC:PMC12409425 OpenAlex:https://openalex.org/W4412555184

NIAID NIH HHS

Grant: R01 AI021747

National Institute of Allergy and Infectious Diseases

National Institutes of Health

University of Connecticut School of Medicine

U.S. Department of Health and Human Services

FWCI

1.45

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://www.jbc.org/article/S0021-9258(25)02348-8/pdf

publisherhttps://www.jbc.org/article/S0021-9258(25)02348-8/pdf

journalhttps://doi.org/10.1016/j.jbc.2025.110498

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40684942

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12409425/

Fields of Study

Herpesvirus Infections and TreatmentsVirus-based gene therapy researchRNA regulation and diseaseVirus ReplicationDNA, Single-StrandedProtein BindingViral ProteinsDNA-Binding ProteinsHerpesvirus 1, HumanHumansDNA, ViralProtein Domains

MeSH Terms

Protein DomainsDNA-Binding ProteinsDNA, Single-StrandedDNA, ViralHumansProtein BindingViral ProteinsVirus ReplicationHerpesvirus 1, Human

Keywords

Herpes simplex virusProtein filamentCell biologyViral replicationAnnealing (glass)ChemistryVirologyVirusBiophysicsBiologyMaterials scienceBiochemistryprotein-protein interactionsSingle Strand AnnealingViral Dna SynthesisIcp8 Dna Binding Protein

Two distinct protein-protein interfaces drive cooperative binding of the herpes simplex virus protein ICP8 to ssDNA, filament formation and annealing essential for viral replication

FAIR Checklist

Authors (8)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)