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Inositol (1,4,5)-trisphosphate 5-phosphatase promotes survival of uveal melanoma by regulating oncogenic G protein–driven calcium oscillations

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110589Source: DataRank Database

Inositol (1,4,5)-trisphosphate 5-phosphatase promotes survival of uveal melanoma by regulating oncogenic G protein–driven calcium oscillations is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (13 grants)Impact (FWCI 0.39)OA: goldTopics (38)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Carol M. Makepeace,Kevin M. Kaltenbronn ORCID,McKenzie Demourelle-Washington,Kisha Piggott ORCID,Dennis Goldfarb ORCID

Live enrichment

PubMed:40812428 PMC:PMC12450637 OpenAlex:https://openalex.org/W4413138523

NIH National Institute of General Medical Sciences

Grant: GM124093

NIH National Institute of General Medical Sciences

Grant: GM138448

NIH National Institute of General Medical Sciences

Grant: GM118171

NIH National Institute of General Medical Sciences

Grant: GM136925

Basic Research Laboratory

Grant: CA234533

NCI NIH HHS

Grant: R01 CA234533

NIGMS NIH HHS

Grant: R01 GM124093

NIGMS NIH HHS

Grant: R35 GM118171

NIGMS NIH HHS

Grant: R01 GM136925

NIGMS NIH HHS

Grant: R01 GM138448

NIGMS NIH HHS

Grant: R35 GM144082

National Institutes of Health

University of Rochester

FWCI

0.39

Citation Percentile

0.6%

Citation Trend

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.jbc.2025.110589

publisherhttps://doi.org/10.1016/j.jbc.2025.110589

publisherhttps://api.elsevier.com/content/article/PII:S0021925825024408?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825024408?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40812428

Fields of Study

Retinal Development and DisordersCellular transport and secretionOcular Oncology and Treatments

MeSH Terms

Inositol Polyphosphate 5-PhosphatasesUveal MelanomaCalciumCell SurvivalHumansMelanomaUveal NeoplasmsInositol 1,4,5-TrisphosphateCalcium SignalingGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein alpha SubunitsCell Line, Tumor

Keywords

GNAQGq alpha subunitInositolInositol trisphosphateCell biologyBiologyPhosphatasePhospholipase CCalcium signalingDiacylglycerol kinaseIntracellularSignal transductionBiochemistryG proteinPhosphorylationMutationReceptorProtein kinase CUveal MelanomaPalmitoylationCalcium CurrentsInositol MetabolismOncogenic G-proteins

Sustainable Development Goals

SDG 0: Good health and well-being

Inositol (1,4,5)-trisphosphate 5-phosphatase promotes survival of uveal melanoma by regulating oncogenic G protein–driven calcium oscillations

FAIR Checklist

Authors (9)

Funding (13 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)