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Activity-based probes and chemical proteomics uncover the biological impact of targeting HMG-CoA Synthase 1 in the mevalonate pathway

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110660Source: DataRank Database

Activity-based probes and chemical proteomics uncover the biological impact of targeting HMG-CoA Synthase 1 in the mevalonate pathway is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (5 grants)OA: goldTopics (17)IDs (PubMed, PMC)Annotations (1)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Liang Sun ORCID,Yi Rao,Alban Ordureau ORCID,Jason S. Lewis ORCID,Heeseon An ORCID

Live enrichment

PubMed:40912656 PMC:PMC12514577

Memorial Sloan-Kettering Cancer Center

Grant: P30CA008748

NCI NIH HHS

Grant: R35 CA232130

Robertson Foundation

National Institutes of Health

Commonwealth Foundation

goldLicense: cc-by

publisherhttps://www.jbc.org/article/S0021-9258(25)02512-8/pdf

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12514577

Europe_PMChttps://europepmc.org/articles/PMC12514577

Europe_PMChttps://europepmc.org/articles/PMC12514577?pdf=render

MeSH Terms

Cell Line, TumorAnimalsHumansMiceMevalonic AcidHydroxymethylglutaryl-CoA SynthaseHydroxymethylglutaryl CoA ReductasesHydroxymethylglutaryl-CoA Reductase InhibitorsEnzyme InhibitorsProteomics

Keywords

StatinMevalonateHmgcrChemical ProteomicsActivity-based ProbeHmgcs1Hymeglusin

Activity-based probes and chemical proteomics uncover the biological impact of targeting HMG-CoA Synthase 1 in the mevalonate pathway

FAIR Checklist

Authors (6)

Funding (5 grants)

Open Access

Topics

Annotations (Europe PMC)