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Nitric oxide regulates cytochrome P450 2D6 and 3A4 activity via concentration-dependent modulation of heme loading

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110772Source: DataRank Database

Nitric oxide regulates cytochrome P450 2D6 and 3A4 activity via concentration-dependent modulation of heme loading is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)Impact (FWCI 0.00)OA: goldTopics (37)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Sidra Islam ORCID,Pranjal Biswas ORCID,Dennis J. Stuehr ORCID,Priya Das Sinha

Live enrichment

PubMed:41022321 PMC:PMC12605048 OpenAlex:https://openalex.org/W4414687126

National Institute of General Medical Sciences

Grant: R01 GM130624

National Institute of General Medical Sciences

Grant: R01 GM148664

National Institutes of Health

FWCI

0.00

Citation Percentile

0.3%

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.jbc.2025.110772

publisherhttps://doi.org/10.1016/j.jbc.2025.110772

publisherhttps://api.elsevier.com/content/article/PII:S0021925825026249?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825026249?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41022321

Fields of Study

Pharmacogenetics and Drug MetabolismErythropoietin and Anemia TreatmentCancer, Hypoxia, and MetabolismHumansCytochrome P-450 CYP3AHemeNitric OxideAnimalsCytochrome P-450 CYP2D6Hep G2 CellsCricetulusCHO CellsCricetinae

MeSH Terms

AnimalsCricetulusCricetinaeHemeHumansNitric OxideCHO CellsCytochrome P-450 CYP2D6Cytochrome P-450 CYP3AHep G2 Cells

Keywords

HemeChinese hamster ovary cellNitric oxideCYP3A4Cytochrome P450Cytochrome P450 reductaseHemeproteinHeme oxygenaseDownregulation and upregulationMitochondriaGAPDHHSP90Heme ProteinHeme Trafficking