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Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response, contributing to heart failure

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110818Source: DataRank Database

Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response, contributing to heart failure is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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Enrichment:Funding (10 grants)Impact (FWCI 0.40)OA: goldTopics (36)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Wenxi Zhang ORCID,Aidan Dunphy,Justin C. Zhong ORCID,C. Cho,Dan R. Turner

Live enrichment

PubMed:41101503 PMC:PMC12661449 OpenAlex:https://openalex.org/W4415184371

National Institutes of Health

Grant: R01HL134821

National Institutes of Health

Grant: T32HL007227

National Institutes of Health

Grant: R01HL139640

American Heart Association Inc

Grant: 935823

National Cancer Institute

Grant: P30 CA016520

National Cancer Institute

Grant: P30DK050306

U.S. Army Medical Research Acquisition Activity

Grant: USAMRAA HT94252410277

NHLBI NIH HHS

Grant: R01 HL164478

NHLBI NIH HHS

Grant: K12 HL141952

NHLBI

FWCI

0.40

Citation Percentile

0.6%

Citation Trend

2026

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.jbc.2025.110818

publisherhttps://doi.org/10.1016/j.jbc.2025.110818

publisherhttps://api.elsevier.com/content/article/PII:S0021925825026705?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825026705?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41101503

Fields of Study

Glycosylation and Glycoproteins ResearchEndoplasmic Reticulum Stress and DiseasePharmacological Effects of Natural Compounds

MeSH Terms

AcetylglucosamineAnimalsHeart FailurePhosphorylationStress, PhysiologicalSignal TransductionEukaryotic Initiation Factor-2Protein Serine-Threonine KinasesN-AcetylglucosaminyltransferasesMice, KnockoutMyocytes, CardiacMiceActivating Transcription Factor 4

Keywords

Heart failureIntracellularTranslation (biology)PhosphorylationSerineMyocyteThreonineSignal transductionIntegrated stress responseEnzymeTranslation initiationCardiomyocytesCardiomyopathyATF4MtorpERKGcn2Eif2αOgtIsrib

Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response, contributing to heart failure

FAIR Checklist

Authors (10)

Funding (10 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)