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Mutagenesis of the PALB2 WD40 domain identifies variants defective in interaction with BRCA2 and DNA repair

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110835Source: DataRank Database

Mutagenesis of the PALB2 WD40 domain identifies variants defective in interaction with BRCA2 and DNA repair is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0.

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refseq uniprot pdb

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (9 grants)Impact (FWCI 0.00)OA: goldTopics (28)IDs (PubMed, PMC, OpenAlex)Annotations (3)

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Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Anna Beatriz Ribeiro Elias ORCID,Huaizhi Huang ORCID,Chunling Hu ORCID,Thales C. Nepomuceno ORCID,Giuliana De Gregoriis ORCID

Live enrichment

PubMed:41109346 PMC:PMC12686622 OpenAlex:https://openalex.org/W4415254911

National Institutes of Health

Grant: R35CA253187

NIH NCI

Grant: P30-CA076292

NCI NIH HHS

Grant: P50 CA116201

NCI NIH HHS

Grant: P30 CA076292

Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro

Fundação do Câncer

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Ovarian Cancer Research Alliance

Breast Cancer Research Foundation

FWCI

0.00

Citation Percentile

0.2%

goldLicense: cc-by-nc-nd

journalhttps://www.jbc.org/article/S0021-9258(25)02687-0/pdf

publisherhttps://www.jbc.org/article/S0021-9258(25)02687-0/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925825026870?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825026870?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2025.110835

Fields of Study

BRCA gene mutations in cancerCRISPR and Genetic EngineeringDNA Repair MechanismsMedicineBiology

MeSH Terms

Protein DomainsFanconi Anemia Complementation Group N ProteinDNA RepairHumansProtein BindingMutagenesisMutation, MissenseBRCA2 ProteinHEK293 CellsRecombinational DNA Repair

Keywords

PALB2Homologous recombinationDNA repairBRCA2 ProteinMutagenesisGeneGermlineMissense mutationCancerFunctional analysisBreast cancerCancer BiologyVus

Mutagenesis of the PALB2 WD40 domain identifies variants defective in interaction with BRCA2 and DNA repair

FAIR Checklist

Authors (13)

Funding (9 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)