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MYBPC3 N-terminal missense mutations linked to hypertrophic cardiomyopathy strengthen actin binding and enhance residue mobility

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110855Source: DataRank Database

MYBPC3 N-terminal missense mutations linked to hypertrophic cardiomyopathy strengthen actin binding and enhance residue mobility is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (7 grants)Impact (FWCI 0.00)OA: goldTopics (38)IDs (PubMed, PMC, OpenAlex)Annotations (1)

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Accessible (1/2)

Open Access

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Reusable (0/3)

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Authors (5)

Thomas A. Bunch ORCID,Fiona L. Wong ORCID,L. Michel Espinoza‐Fonseca ORCID,Brett A. Colson ORCID,Rhye‐Samuel Kanassatega ORCID

Live enrichment

PubMed:41135679 PMC:PMC12666836 OpenAlex:https://openalex.org/W4415448126

National Heart Lung and Blood Institute Division of Intramural Research

Grant: T32 HL007249

National Heart Lung and Blood Institute Division of Intramural Research

Grant: R01 HL141564

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Grant: R01 AR079435

American Heart Association Inc

Grant: 23PRE1013852

American Heart Association Inc

Grant: 916744

National Institutes of Health

University of Arizona

FWCI

0.00

Citation Percentile

0.4%

goldLicense: http://creativecommons.org/licenses/by-nc-nd/4.0/

journalhttps://www.jbc.org/article/S0021-9258(25)02707-3/pdf

publisherhttps://www.jbc.org/article/S0021-9258(25)02707-3/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925825027073?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825027073?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2025.110855

Fields of Study

Cardiomyopathy and Myosin StudiesNuclear Structure and FunctionCardiovascular Effects of ExerciseCardiomyopathy, HypertrophicMutation, MissenseActinsHumansCarrier ProteinsProtein BindingMolecular Dynamics SimulationPhosphorylationProtein DomainsProtein StabilityMyosin Binding Protein C

MeSH Terms

Protein DomainsMyosin Binding Protein CActinsCardiomyopathy, HypertrophicCarrier ProteinsHumansPhosphorylationProtein BindingMutation, MissenseProtein StabilityMolecular Dynamics Simulation

Keywords

Missense mutationAllosteric regulationHypertrophic cardiomyopathyMutantActinMutationPoint mutationResidue (chemistry)Missense MutationsActin-binding ProteinsCardiac Myosin-binding Protein C (Cmybp-c)Hypertrophic Cardiomyopathy (Hcm)Molecular Dynamics (Md) Simulations

MYBPC3 N-terminal missense mutations linked to hypertrophic cardiomyopathy strengthen actin binding and enhance residue mobility

FAIR Checklist

Authors (5)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)