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An evolutionary T119R substitution in the macaque T-cell immunoreceptor TIGIT enables proteolytic shedding and reveals clinical antibody vulnerabilities

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110962Source: DataRank Database

An evolutionary T119R substitution in the macaque T-cell immunoreceptor TIGIT enables proteolytic shedding and reveals clinical antibody vulnerabilities is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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0DataRank · unranked

Scored on demand from live citation data

Open Access1 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (7 grants)OA: goldTopics (14)IDs (PubMed, PMC)Annotations (2)

FAIR Checklist

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Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Francis Freenor,Brice E. N. Wamba,Sanchita Bhatnagar ORCID,Tanmoy Mondal ORCID,Jogender Tushir‐Singh ORCID

Live enrichment

PubMed:41274505 PMC:PMC12853184

National Institutes of Health National Cancer Institute

Grant: R01CA233752

US Department of Defense

Grant: OC180412

NCI NIH HHS

Grant: P30 CA093373

Ovarian Cancer Alliance of Greater Cincinnati

California National Primate Research Center

National Institutes of Health

University of California, Davis

goldLicense: cc-by-nc-nd

publisherhttps://www.jbc.org/article/S0021-9258(25)02814-5/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925825028145?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825028145?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12853184

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12853184/

MeSH Terms

T-LymphocytesAnimalsMacaca mulattaHumansReceptors, ImmunologicReceptors, VirusEvolution, MolecularProteolysis

Keywords

Antibody engineeringProtein degradationCancer ImmunotherapyImmunotherapeuticsProtein RegulationImmune Checkpoint Signaling