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Epitope-specific antibodies can distinguish between soluble huntingtin exon-1 and its diverse cellular aggregates

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.111048Source: DataRank Database

Epitope-specific antibodies can distinguish between soluble huntingtin exon-1 and its diverse cellular aggregates is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (4 grants)Impact (FWCI 0.00)OA: goldTopics (28)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Hui Xu ORCID,Jeannie Chen ORCID,Ali Khoshnan ORCID,Ralf Langen ORCID,J. E. Lugo ORCID

Live enrichment

PubMed:41391760 PMC:PMC12816906 OpenAlex:https://openalex.org/W4417279026

National Institutes of Health

Grant: NS118859

National Institutes of Health

Grant: NS120704

National Institutes of Health

Grant: NS125769

NINDS NIH HHS

Grant: R01 NS125769

FWCI

0.00

Citation Percentile

0.3%

goldLicense: cc-by

journalhttps://doi.org/10.1016/j.jbc.2025.111048

publisherhttps://doi.org/10.1016/j.jbc.2025.111048

publisherhttps://api.elsevier.com/content/article/PII:S002192582502900X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S002192582502900X?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41391760

Fields of Study

Genetic Neurodegenerative DiseasesAmyotrophic Lateral Sclerosis ResearchAutoimmune Neurological Disorders and Treatments

MeSH Terms

Huntingtin ProteinAnimalsAntibodiesEpitopesExonsHumansHuntington DiseasePeptidesMiceHEK293 CellsProtein Aggregates

Keywords

HuntingtinFibrilHEK 293 cellsHuntingtin ProteinAntibodyAmyloid (mycology)Protein aggregationPlasma protein bindingMonomerRecombinant DNABiomarkerElectron paramagnetic resonanceHuntington's diseasePolyglutamine