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Enhanced lysosomal activity prevents infection with PrPSc and the seeding activity of α-synuclein & tau prions

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.111050Source: DataRank Database

Enhanced lysosomal activity prevents infection with PrPSc and the seeding activity of α-synuclein & tau prions is a research paper published in Journal of Biological Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Scored on demand from live citation data

Open Access2 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (8 grants)Impact (FWCI 0.79)OA: goldTopics (40)IDs (PubMed, PMC, OpenAlex)Annotations (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (15)

Nhat T. T. Le ORCID,Nadia Mirza ORCID,Isabel C. Orbe ORCID,Erin Flaherty ORCID,Joseph P. DeFranco ORCID

Live enrichment

PubMed:41391758 PMC:PMC12805356 OpenAlex:https://openalex.org/W4417290042

Foundation for the National Institutes of Health

Grant: 5R01NS065244

US Department of Defense

Grant: W81XWH-21-1-0141

National Institute of Mental Health

Grant: HHSN-271-2018-00023-C

NIAID NIH HHS

Grant: P01 AI077774

NINDS NIH HHS

Grant: R01 NS065244

NINDS NIH HHS

Grant: R21 NS107755

NINDS NIH HHS

Grant: R21 NS101659

Creutzfeldt-Jakob Disease Foundation Inc

FWCI

0.79

Citation Percentile

0.7%

Citation Trend

2026

goldLicense: cc-by-nc-nd

journalhttps://www.jbc.org/article/S0021-9258(25)02902-3/pdf

publisherhttps://www.jbc.org/article/S0021-9258(25)02902-3/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925825029023?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925825029023?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jbc.2025.111050

Fields of Study

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatmentsLysosomal Storage Disorders ResearchMedicineBiologyLysosomesalpha-SynucleinAnimalsPrPSc ProteinsHumanstau ProteinsMicePrion DiseasesBasic Helix-Loop-Helix Leucine Zipper Transcription Factors

MeSH Terms

AnimalsHumansLysosomestau ProteinsPrion DiseasesPrPSc ProteinsMiceBasic Helix-Loop-Helix Leucine Zipper Transcription Factorsalpha-Synuclein

Keywords

TFEBLysosomeAutophagyGenePrion proteinTranscriptomeAmyloid (mycology)Lipid metabolismPrionTauNeurodegenerationTherapeuticsPrPMSAFtldA-synucleinA-syn

Enhanced lysosomal activity prevents infection with PrPSc and the seeding activity of α-synuclein & tau prions

FAIR Checklist

Authors (15)

Funding (8 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)