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SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells

Cellular and Molecular Gastroenterology and Hepatology(2020)10.1016/j.jcmgh.2020.04.005Source: DataRank Database

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells is a research paper published in Cellular and Molecular Gastroenterology and Hepatology (2020). On theSindex it has a DataRank of 0. It has been cited 92 times.

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Open Access92 citations

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Enrichment:Funding (6 grants)OA: goldTopics (52)IDs (PubMed)SDGs (1)

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Authors (10)

Menghao Huang ORCID,Hyeong-Geug Kim,Yang Zhang ORCID,Kushan Chowdhury ORCID,Wenjie Cai ORCID

Live enrichment

PubMed:32305562

National Institutes of Health

Grant: 1R21AA024550-01A1

Role of sirtuin 6 in the protection of liver from the alcohol-induced injury

National Institutes of Health

Grant: 5R01DK107682-02

Sestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver disease

National Institutes of Health

Grant: 1ZIADK013039-04

Molecular modeling of soluble proteins

National Institutes of Health

Grant: 5P30DK097512-08

Indiana Diabetes Research Center

National Institutes of Health

Grant: 2R56DK091592-06A1

Regulation of hepatic lipid metabolism

National Institutes of Health

Grant: 5UL1TR002529-02

Indiana Clinical and Translational Sciences Institute

goldLicense: cc-by-nc-nd

publisherhttps://doi.org/10.1016/j.jcmgh.2020.04.005

repositoryhttps://doaj.org/article/c06b524905434e42ad26ee0957994494

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7327931

repositoryhttps://hdl.handle.net/1805/24446

repositoryhttp://hdl.handle.net/1805/24446

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

green fluorescent proteinLiver CirrhosisMaleSMAD3 SMAD family member 3SteatosisKO knockoutNonalcoholic SteatohepatitisRC799-869MiceNon-alcoholic Fatty Liver DiseaseSirtuin 6SirtuinstransferasemWestern diettransforming growth factor βhepatic stellate cellOriginal ResearchMice, KnockoutAcetylationDiseases of the digestive system. GastroenterologyMiddle AgedLiverGene Knockdown TechniquesNASH nonalcoholic steatohepatitisFemalePBS phosphate-buffered salineAdultDeacetylationalanine aminotransferasePrimary Cell Culturechromatin immunoprecipitationNAFLD nonalcoholic fatty liver diseaseCell LineHepatic Stellate CellsAnimalsHumansSIRT6 sirtuin 6hemagglutinintransgenicAgedhRNA short hairpin RNAwild-typeInflammationRNA messengerGene Expression RegulationMutationLratlecithin retinol acylPCR polymerase chain reactionsDulbecco’s modified Eagle medium

Sustainable Development Goals

SDG 3: 3. Good health