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Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis

Cellular and Molecular Gastroenterology and Hepatology(2022)10.1016/j.jcmgh.2022.06.007Source: DataRank Database

Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis is a research paper published in Cellular and Molecular Gastroenterology and Hepatology (2022). On theSindex it has a DataRank of 0. It has been cited 45 times.

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Open Access45 citations

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Enrichment:Funding (6 grants)Impact (FWCI 6.15)OA: goldTopics (92)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

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Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Lin Kui ORCID,Agustina Reca,Aleksandra Leszczynska ORCID,Andrea D. Kim,Laela M. Booshehri ORCID

Live enrichment

PubMed:35787975 PMC:PMC9424559 OpenAlex:https://openalex.org/W4283780323

National Institutes of Health

Grant: R01 AA024206

National Institutes of Health

Grant: R01 DK113592

Deutsche Forschungsgemeinschaft

Grant: KA 5089/1-1

National Institutes of Health

Grant: 5R01DK113592-05

Sterile inflammation and pyroptotic cell death in liver fibrosis

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R01AA024206-03

Gain of function mutations in inflammasome related genes in human and experimental alcoholic liver disease

FWCI

6.15

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.jcmgh.2022.06.007

publisherhttps://doi.org/10.1016/j.jcmgh.2022.06.007

publisherhttps://api.elsevier.com/content/article/PII:S2352345X22001503?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2352345X22001503?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35787975

Fields of Study

Liver Disease Diagnosis and TreatmentInflammasome and immune disordersLiver Disease and Transplantation0301 basic medicine03 medical and health sciences0303 health sciencesAdenosineAmino AcidsAnimalsCaspasesCholineHepatitisHumansInflammasomesInflammationInterleukin-1betaLipopolysaccharidesLiver CirrhosisMiceMice, KnockoutMyeloid CellsNLR Family, Pyrin Domain-Containing 3 ProteinNon-alcoholic Fatty Liver DiseasePolyphosphates

MeSH Terms

NLR Family, Pyrin Domain-Containing 3 ProteinAdenosineAmino AcidsAnimalsCholineHepatitisHumansInflammationLipopolysaccharidesLiver CirrhosisPolyphosphatesMice, KnockoutCaspasesMyeloid CellsMiceInterleukin-1betaInflammasomesNon-alcoholic Fatty Liver Disease

Keywords

InflammasomeNonalcoholic fatty liver diseaseInflammationHepatic stellate cellSteatohepatitisMyeloidFibrosisLiver injurySteatosisCancer researchBiologyImmunologyFatty liverMedicineInternal medicineEndocrinologyFibrogenesisLiver InflammationNlr Family Pyrin Domain Containing 3LipopolysaccharidesLiver Cirrhosis570AdenosineInflammasomesKnockoutChronic Liver Disease and CirrhosisInterleukin-1beta610NLR FamilyOral and gastrointestinalCholineHepatitisMiceNon-alcoholic Fatty Liver DiseasePolyphosphatesNLR Family, Pyrin Domain-Containing 3 Protein2.1 Biological and endogenous factorsAnimalsHumansMyeloid CellsAetiologyAmino AcidsNutritionOriginal ResearchMice, KnockoutLiver DiseaseInflammatory and immune systemPyrin Domain-Containing 3 ProteinCaspasesDigestive Diseases

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis

FAIR Checklist

Authors (12)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)