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An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Journal of Hepatology(2021)10.1016/j.jhep.2021.04.055Source: DataRank Database

An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs is a research paper published in Journal of Hepatology (2021). On theSindex it has a DataRank of 0. It has been cited 186 times.

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Open Access186 citations

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Enrichment:Funding (32 grants)Impact (FWCI 9.66)OA: hybridTopics (54)Linked Datasets (18)DataCite Reuse (18)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

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Findable (2/2)

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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (94)

James J. Fryett ORCID,Kazuko Ueno ORCID,Rebecca Darlay ORCID,Yoshihiro Aiba ORCID,Yuki Hitomi ORCID

Live enrichment

PubMed:34033851 PMC:PMC8811537 OpenAlex:https://openalex.org/W3165249197

Japan Society for the Promotion of Science

Grant: 26293181

Japan Society for the Promotion of Science

Grant: 17H04169

Biotechnology and Biological Sciences Research Council

Grant: BB/M011186/1

Newcastle Liverpool Durham BBSRC DTP2

Ontario Research Foundation

Grant: RE-09090

Cancer Prevention and Research Institute of Texas

Grant: CA186566

Cancer Prevention and Research Institute of Texas

Grant: RR170048

Canadian Institutes of Health Research

Grant: 353710

Wellcome Trust

Grant: 102858/Z/13/Z

Japan Agency for Medical Research and Development

Grant: JP20km0405205

Japan Agency for Medical Research and Development

Grant: JP20km0405501

Medical Research Council

Grant: MR/L001489/1

Stratified Medicine in Primary Biliary Cirrhosis (PBC): Understanding Disease Mechanisms and Targeting Therapies (UK-PBC)

Medical Research Council

Grant: 217065/Z/19/Z

National Institutes of Health

Grant: DK80670

Biotechnology and Biological Sciences Research Council

Grant: BB/I025263/1

Accessible resource for integrated epigenomics studies (ARIES)

Biotechnology and Biological Sciences Research Council

Grant: BBI025751/1

Medical Research Council

Grant: G9815508

National Institute for Health Research (NIHR)

Grant: NIHR200243

Wellcome Trust

Grant: WT088806

National Institute for Health Research (NIHR)

Grant: NF-SI-0513-10091

Medical Research Council

Grant: MC_PC_15018

Medical Research Council

Grant: MC_PC_19009

Wellcome Trust

Grant: 217065

The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being.

Wellcome Trust

Grant: 088806

Genome-wide association study of maternal pregnancy phenotypes and later-life maternal and offspring vascular and metabolic phenotypes.

Ministero dell'Istruzione dell'Università e della Ricerca

Grant: unidentified

unidentified

Wellcome Trust

Grant: 102858

Development and application of statistical methodology for the detection and characterisation of genetic factors in complex disease.

American Medical Association Foundation

University of Bristol

National Institute for Health Research (NIHR)

Ministero dell’Istruzione, dell’Università e della Ricerca

Wellcome Trust

Department of Health

Wellcome Trust

FWCI

9.66

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1016/j.jhep.2021.04.055

publisherhttps://doi.org/10.1016/j.jhep.2021.04.055

publisherhttps://api.elsevier.com/content/article/PII:S0168827821003342?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0168827821003342?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34033851

Fields of Study

Liver Diseases and ImmunityDrug Transport and Resistance MechanismsPediatric Hepatobiliary Diseases and Treatments0301 basic medicine03 medical and health sciencesGenome-Wide Association StudyHumansLiver Cirrhosis, Biliary

MeSH Terms

HumansLiver Cirrhosis, BiliaryGenome-Wide Association Study

Keywords

BiologyGenome-wide association studyCandidate geneGeneticsGenomeBioinformaticsGeneInternal medicineMedicineGenotypeSingle-nucleotide polymorphismAlspacUk-pbcGenomic Co-localizationNetwork-based In Silico Drug Efficacy ScreeningErn Rare-liverLiver CirrhosisALSPAC; ERN RARE-LIVER; Genomic co-localization; Network-based in silico drug efficacy screening; UK-PBCItalian PBC Study GroupALSPAC; ERN RARE-LIVER; Genomic co-localization; Network-based in silico drug efficacy screening; UK-PBC; Genome-Wide Association Study; Humans; Liver Cirrhosis, BiliaryLD SCORE REGRESSIONJapan-PBC-GWAS Consortium610SUSCEPTIBILITYALSPAC; ERN RARE-LIVER; Genomic co-localization; Network-based in silico drug efficacy screening; UK-PBC;PBCGENETIC ASSOCIATION1117 Public Health and Health ServicesALSPAC; ERN RARE-LIVER; Genomic co-localization; Network-based in silico drug efficacy screening; UK-PBC; PBC Consortium; Italian PBC Study GroupUK-PBC ConsortiumHumansScience & TechnologyGastroenterology & HepatologyLiver Cirrhosis, BiliaryBiliaryChinese PBC Consortium1103 Clinical SciencesPBC ConsortiaERN RARE LIVERUS PBC ConsortiumCanadian PBC ConsortiumLife Sciences & BiomedicineResearch Article

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 2 of Genetic evidence of the causal relationship between chronic liver diseases and musculoskeletal disorders

10.6084/m9.figshare.25157771.v1figshare

Additional file 2 of Genetic evidence of the causal relationship between chronic liver diseases and musculoskeletal disorders

10.6084/m9.figshare.25157771figshare

Additional file 1 of Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis

10.6084/m9.figshare.26019517.v1figshare

Additional file 1 of Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis

10.6084/m9.figshare.26019517figshare

Additional file 2 of Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis

10.6084/m9.figshare.26019707.v1figshare

Additional file 2 of Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis

10.6084/m9.figshare.26019707figshare

Additional file 1 of Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis

10.6084/m9.figshare.26706321.v1figshare

Additional file 1 of Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis

10.6084/m9.figshare.26706321figshare

Additional file 1 of Primary biliary cholangitis has causal effects on systemic rheumatic diseases: a Mendelian randomization study

10.6084/m9.figshare.26944050.v1figshare

Additional file 1 of Primary biliary cholangitis has causal effects on systemic rheumatic diseases: a Mendelian randomization study

10.6084/m9.figshare.26944050figshare

Additional file 3 of Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis

10.6084/m9.figshare.26732416.v1figshare

Additional file 3 of Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis

10.6084/m9.figshare.26732416figshare

Additional file 1 of Genetic evidence of the causal relationship between chronic liver diseases and musculoskeletal disorders

10.6084/m9.figshare.25157397.v1figshare

Additional file 1 of Genetic evidence of the causal relationship between chronic liver diseases and musculoskeletal disorders

10.6084/m9.figshare.25157397figshare

Additional file 2 of Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis

10.6084/m9.figshare.26706324.v1figshare

Additional file 2 of Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis

10.6084/m9.figshare.26706324figshare

Additional file 1 of Causal effects of gut microbiome on autoimmune liver disease: a two-sample Mendelian randomization study

10.6084/m9.figshare.24240120.v1figshare

Additional file 1 of Causal effects of gut microbiome on autoimmune liver disease: a two-sample Mendelian randomization study

10.6084/m9.figshare.24240120figshare

An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

FAIR Checklist

Authors (94)

Funding (32 grants)

Impact

Open Access

Topics

Linked Datasets (18)

Annotations (Europe PMC)