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Specific Conformational Dynamics and Expansion Underpin a Multi-Step Mechanism for Specific Binding of p27 with Cdk2/Cyclin A

Journal of Molecular Biology(2020)10.1016/j.jmb.2020.02.010Source: DataRank Database

Specific Conformational Dynamics and Expansion Underpin a Multi-Step Mechanism for Specific Binding of p27 with Cdk2/Cyclin A is a research paper published in Journal of Molecular Biology (2020). On theSindex it has a DataRank of 0. It has been cited 33 times.

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Open Access33 citations

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Enrichment:Funding (12 grants)Impact (FWCI 1.90)OA: hybridTopics (70)IDs (PubMed, PMC, OpenAlex)Annotations (3)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Katherina Hemmen ORCID,George L. Hamilton ORCID,Narendar Kolimi ORCID,Suren Felekyan ORCID,Claus A. M. Seidel ORCID

Live enrichment

PubMed:32088186 PMC:PMC7254055 OpenAlex:https://openalex.org/W3007967610

Seventh Framework Programme

Grant: 330847 – STARIDP

Engineering Research Centers

Grant: 671208

hybridFRET - deciphering biomolecular structure and dynamics

National Science Foundation

Grant: MCB- 1749778

Fonds Wetenschappelijk Onderzoek

Grant: K124670

Fonds Wetenschappelijk Onderzoek

Grant: K131702

National Institutes of Health

Grant: P20GM121342

Clemson University

Grant: G.0029.12

European Commission

Grant: 330847

Structure and function of intrinsically disordered proteins (IDPs) in cell cycle regulation

National Science Foundation

Grant: 1749778

CAREER: Structural dynamics of post-translationally modified Calmodulin and its role in target recognition

National Institutes of Health

Grant: 3P20GM121342-03S1

SARS-CoV2 sequencing surveillance program for Upstate South Carolina

H2020 Marie Skłodowska-Curie Actions

Hungarian Scientific Research Fund

FWCI

1.90

Citation Percentile

0.9%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.jmb.2020.02.010

publisherhttps://doi.org/10.1016/j.jmb.2020.02.010

publisherhttps://api.elsevier.com/content/article/PII:S0022283620301601?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0022283620301601?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/32088186

Fields of Study

Cancer-related Molecular PathwaysEnzyme Structure and FunctionProtein Structure and Dynamics0301 basic medicine0303 health sciences03 medical and health sciencesBinding SitesCyclin ACyclin-Dependent Kinase 2Cyclin-Dependent Kinase Inhibitor p27Fluorescence Resonance Energy TransferHumansModels, MolecularMutationProtein BindingProtein ConformationSingle Molecule ImagingSpectrometry, FluorescenceTernary Complex Factors

MeSH Terms

Single Molecule ImagingBinding SitesHumansModels, MolecularMutationProtein BindingProtein ConformationSpectrometry, FluorescenceCyclin AFluorescence Resonance Energy TransferCyclin-Dependent Kinase Inhibitor p27Ternary Complex FactorsCyclin-Dependent Kinase 2

Keywords

Cyclin-dependent kinase 2Cyclin ABiophysicsTernary complexChemistryCyclin-dependent kinase complexConformational changeCyclinCyclin-dependent kinaseBinding siteCrystallographyCell cycleCell biologyKinaseBiologyBiochemistryProtein kinase ACellEnzymep27Fluorescence Correlation SpectroscopyIdpStopped-flow KineticsSingle Molecule FretReplica Exchange Discrete Molecular Dynamic SimulationsSingle Molecule Fluorescence AnisotropyModels, MolecularBinding SitesProtein ConformationTernary Complex FactorsArticleSingle Molecule ImagingSpectrometry, FluorescenceMutationFluorescence Resonance Energy TransferHumansCyclin-Dependent Kinase Inhibitor p27Protein Binding

Specific Conformational Dynamics and Expansion Underpin a Multi-Step Mechanism for Specific Binding of p27 with Cdk2/Cyclin A

FAIR Checklist

Authors (8)

Funding (12 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)