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Structure-based Discovery of a Non-competitive FTO Inhibitor Bound to a Cryptic Site at the Domain Interface

Journal of Molecular Biology(2025)10.1016/j.jmb.2025.169575Source: DataRank Database

Structure-based Discovery of a Non-competitive FTO Inhibitor Bound to a Cryptic Site at the Domain Interface is a research paper published in Journal of Molecular Biology (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Enrichment:Funding (4 grants)Impact (FWCI 0.38)OA: greenTopics (35)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Francesco Pettini ORCID,Beatrice Gianibbi ORCID,Shweta Das ORCID,Donatella Barisani ORCID,Jeffrey A. Purslow ORCID

Live enrichment

PubMed:41354147 PMC:PMC12709851 OpenAlex:https://openalex.org/W4417027813

National Institutes of Health

Grant: S10-OD032235

National Institute of General Medical Sciences

Grant: R35GM133488

NIH HHS

Grant: S10 OD032235

Iowa State University

FWCI

0.38

Citation Percentile

0.6%

Citation Trend

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12709851/pdf/nihms-2128245.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0022283625006412?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0022283625006412?httpAccept=text/plain

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12709851/

Fields of Study

Microbial metabolism and enzyme functionRNA modifications and cancerPeroxisome Proliferator-Activated ReceptorsAlpha-Ketoglutarate-Dependent Dioxygenase FTOEnzyme InhibitorsMolecular Dynamics SimulationHumansProtein BindingBinding SitesDrug DiscoveryKineticsProtein Domains

MeSH Terms

Alpha-Ketoglutarate-Dependent Dioxygenase FTOProtein DomainsBinding SitesEnzyme InhibitorsHumansKineticsProtein BindingDrug DiscoveryMolecular Dynamics Simulation

Keywords

Small moleculeAllosteric regulationVirtual screeningAlkBDrug discoveryEnzymeSubfamilyProtein–protein interactionPlasma protein bindingNMRprotein dynamicsN(6)-methyladenosineAlkb EnzymesNucleic Acid Demethylase

Structure-based Discovery of a Non-competitive FTO Inhibitor Bound to a Cryptic Site at the Domain Interface

FAIR Checklist

Authors (9)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)