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Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome c

Osteoarthritis and Cartilage(2020)10.1016/j.joca.2020.08.014Source: DataRank Database

Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome c is a research paper published in Osteoarthritis and Cartilage (2020). On theSindex it has a DataRank of 0. It has been cited 71 times.

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Open Access71 citations

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Enrichment:Funding (3 grants)Impact (FWCI 6.15)OA: greenTopics (56)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Hope C. Ball ORCID,S. Wase ORCID,K. Novak,Tariq M. Haqqi ORCID,Mohammad Y. Ansari ORCID

Live enrichment

PubMed:33161099 PMC:PMC8418332 OpenAlex:https://openalex.org/W3017337165

NIAMS NIH HHS

Grant: R01 AR067056

NCCIH NIH HHS

Grant: R01 AT007373

National Institutes of Health

FWCI

6.15

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8418332

publisherhttps://api.elsevier.com/content/article/PII:S1063458420311626?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1063458420311626?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.joca.2020.08.014

Fields of Study

Osteoarthritis Treatment and MechanismsCalcium signaling and nucleotide metabolismAutophagy in Disease and TherapyAgingAnimalsApoptosisArthritis, ExperimentalCartilage, ArticularChondrocytesCytochromes cHumansLysosomal-Associated Membrane Protein 2LysosomesMembrane Potential, MitochondrialMenisci, TibialMiceMitochondriaOsteoarthritis, KneeSuperoxidesbcl-2-Associated X Protein

MeSH Terms

AgingAnimalsArthritis, ExperimentalCartilage, ArticularHumansLysosomesMenisci, TibialMitochondriaSuperoxidesApoptosisChondrocytesOsteoarthritis, KneeCytochromes cbcl-2-Associated X ProteinMiceLysosomal-Associated Membrane Protein 2Membrane Potential, Mitochondrial

Keywords

Cell biologyChondrocyteCytochrome cLysosomeApoptosisMitochondrionMitochondrial apoptosis-induced channelChemistryProgrammed cell deathCartilageBiologyBiochemistryAnatomyAgeingRedoxLysosomesMitochondrial DysfunctionLamp1Lamp2

Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome c

FAIR Checklist

Authors (5)

Funding (3 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)