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Development and validation of a sensitive LC-MS/MS assay of GT-14, a novel Gαi2 inhibitor, in rat plasma, and its application in pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis(2024)10.1016/j.jpba.2024.116183Source: DataRank Database

Development and validation of a sensitive LC-MS/MS assay of GT-14, a novel Gαi2 inhibitor, in rat plasma, and its application in pharmacokinetic study is a research paper published in Journal of Pharmaceutical and Biomedical Analysis (2024). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.37)OA: greenTopics (41)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Jing Ma ORCID,Subhasish Tapadar,Silvia Caggia ORCID,Adegboyega K. Oyelere ORCID,Shafiq A. Khan ORCID

Live enrichment

PubMed:38744031 PMC:PMC11138141 OpenAlex:https://openalex.org/W4396621358

Cancer Prevention and Research Institute of Texas

Grant: RP180748

NIMHD

Grant: U54 MD007605-27A

NIMHD NIH HHS

Grant: U54 MD007605

NIMHD NIH HHS

Grant: G12 MD007605

National Institutes of Health

FWCI

0.37

Citation Percentile

0.6%

Citation Trend

2025

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11138141/pdf/nihms-1996165.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0731708524002231?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0731708524002231?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11138141

Fields of Study

Blood disorders and treatmentsProtein Kinase Regulation and GTPase SignalingCaveolin-1 and cellular processesAnimalsMaleRatsGriseofulvinLiquid Chromatography-Mass SpectrometryProtein BindingRats, Sprague-DawleyReproducibility of ResultsSpectrometry, Mass, Electrospray IonizationTandem Mass Spectrometry

MeSH Terms

Liquid Chromatography-Mass SpectrometryAnimalsChromatography, High Pressure LiquidChromatography, LiquidGriseofulvinMaleProtein BindingReproducibility of ResultsRats, Sprague-DawleySpectrometry, Mass, Electrospray IonizationRatsTandem Mass Spectrometry

Keywords

ChemistryChromatographyPharmacokineticsSelected reaction monitoringElectrospray ionizationElectrosprayExtraction (chemistry)In vivoMatrix (chemical analysis)Tandem mass spectrometryMass spectrometryPharmacologyValidationLC-MS/MSPlasma Protein BindingGαi2 Inhibitor

Development and validation of a sensitive LC-MS/MS assay of GT-14, a novel Gαi2 inhibitor, in rat plasma, and its application in pharmacokinetic study

FAIR Checklist

Authors (7)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)