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Kidney-specific delivery of a matrix metalloproteinase-2 inhibitory peptide fused to elastin-like polypeptide reduces proteinuria and renal fibrosis in a model of salt-sensitive hypertension

Journal of Pharmacology and Experimental Therapeutics(2025)10.1016/j.jpet.2025.103556Source: DataRank Database

Kidney-specific delivery of a matrix metalloproteinase-2 inhibitory peptide fused to elastin-like polypeptide reduces proteinuria and renal fibrosis in a model of salt-sensitive hypertension is a research paper published in Journal of Pharmacology and Experimental Therapeutics (2025). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Open Access6 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 2.93)OA: greenTopics (51)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Heather Chapman,Richard J. Roman ORCID,Gene L. Bidwell ORCID,Adesanya A. Akinleye ORCID

Live enrichment

PubMed:41478668 OpenAlex:https://openalex.org/W7117536053

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: DK130598

NIH National Institute of General Medical Sciences

Grant: P30GM149404

NIH National Institute of General Medical Sciences

Grant: P20GM104357

National Heart Lung and Blood Institute

Grant: HL095638

National Heart Lung and Blood Institute

Grant: HL138685

NIA NIH HHS

Grant: R01 AG079336

FWCI

2.93

Citation Percentile

0.9%

Citation Trend

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13095420/

publisherhttps://api.elsevier.com/content/article/PII:S0022356525397697?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0022356525397697?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jpet.2025.103556

Fields of Study

Protease and Inhibitor MechanismsChronic Kidney Disease and DiabetesBlood Coagulation and Thrombosis MechanismsAnimalsFibrosisMatrix Metalloproteinase 2KidneyProteinuriaElastinHypertensionRatsMaleRats, Inbred DahlMatrix Metalloproteinase InhibitorsPeptidesDisease Models, AnimalDrug Delivery SystemsHumansRecombinant Fusion ProteinsElastin-Like Polypeptides

MeSH Terms

Elastin-Like PolypeptidesAnimalsDisease Models, AnimalElastinFibrosisHumansHypertensionKidneyMalePeptidesProteinuriaRecombinant Fusion ProteinsDrug Delivery SystemsRats, Inbred DahlMatrix Metalloproteinase 2RatsMatrix Metalloproteinase Inhibitors

Keywords

In vivoFusion proteinFibrosisMatrix metalloproteinaseKidneyProteinuriaKidney diseaseExtracellular matrixBiologicsElastin-like polypeptideMatrix metalloproteinase-2PharmacokineticsRenal fibrosisRenal injury

Sustainable Development Goals

SDG 0: Good health and well-being