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The thrombin mutant Trp215Ala/Glu217Ala induces cytoprotective signaling in endothelial cells by cleavage of Arg46 of protease-activated receptor 1

Journal of Thrombosis and Haemostasis(2025)10.1016/j.jtha.2025.11.034Source: DataRank Database

The thrombin mutant Trp215Ala/Glu217Ala induces cytoprotective signaling in endothelial cells by cleavage of Arg46 of protease-activated receptor 1 is a research paper published in Journal of Thrombosis and Haemostasis (2025). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)Impact (FWCI 0.00)OA: greenTopics (43)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (2)

Alireza R. Rezaie ORCID,Indranil Biswas ORCID

Live enrichment

PubMed:41482217 OpenAlex:https://openalex.org/W7117750264

National Heart Lung and Blood Institute

Grant: HL101917

NHLBI NIH HHS

Grant: R01 HL101917

National Institutes of Health

FWCI

0.00

Citation Percentile

0.7%

greenLicense: http://creativecommons.org/licenses/by-nc-nd/4.0/

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41482217/

publisherhttps://api.elsevier.com/content/article/PII:S1538783625009249?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1538783625009249?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.jtha.2025.11.034

Fields of Study

Blood Coagulation and Thrombosis MechanismsProtease and Inhibitor MechanismsVitamin K Research StudiesHumansThrombinReceptor, PAR-1Signal TransductionEndothelial CellsProtein CThrombomodulinHEK293 CellsCytoprotectionProteolysisArginineMutationTransfectionHuman Umbilical Vein Endothelial Cells

MeSH Terms

ArginineHumansMutationProtein CThrombinTransfectionSignal TransductionThrombomodulinCytoprotectionEndothelial CellsReceptor, PAR-1HEK293 CellsProteolysisHuman Umbilical Vein Endothelial Cells

Keywords

ThrombinCleavage (geology)MutantReceptorThrombin receptorSignal transductionProtein CSignalingThrombomodulinEndothelial CellsCytoprotectiveWe-thrombin