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The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease

Kidney International(2020)10.1016/j.kint.2020.05.040Source: DataRank Database

The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease is a research paper published in Kidney International (2020). On theSindex it has a DataRank of 0. It has been cited 24 times.

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Open Access24 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (12 grants)OA: hybridTopics (26)IDs (PubMed)

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Authors (9)

Jonathan R Gadsby ORCID,Beatrice Paola Festa ORCID,Richard Butler ORCID,Stephen P. Jackson ORCID,Valeria Berno ORCID

Live enrichment

PubMed:19910364

Wellcome Trust

Grant: 209749/Z/17/Z

Wellcome Trust

Grant: 092096

Core support for the Wellcome Trust Cancer Research UK Gurdon Institute.

Wellcome Trust

Grant: 219482/Z/19/Z

Wellcome Trust

Grant: 206388/Z/17/Z

Wellcome Trust

Grant: 18.23

Cancer Research UK

Grant: C6946/A14492

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Grant: 310030_189044

European Research Council

Grant: 281971

Membrane-triggered actin polymerisation: molecular mechanisms and morphogenesis

Swiss National Science Foundation

Grant: 189044

Uromodulin: from physiology to genetic susceptibility to disease

Wellcome Trust

Grant: 206388

Genetic and functional interactions in the mammalian DNA-damage response

Wellcome Trust

Grant: 219482

How filopodia form

Wellcome Trust

Grant: 209749

Institutional Translation Partnership Award (iTP A): University of Cambridge

hybridLicense: cc-by

publisherhttp://www.kidney-international.org/article/S0085253820306876/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0085253820306876?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0085253820306876?httpAccept=text/plain

repositoryhttp://hdl.handle.net/2078.1/250723

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7550850

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

610 Medicine & health10052 Institute of PhysiologylipidsMicePhosphatidylinositol 3-KinasesPhosphatidylinositol Phosphatesproximal tubuleendocytosisHumansAnimals610 Medicine & healthPhosphoinositide-3 Kinase InhibitorsDent Disease2727 Nephrologycytoskeletonrenal Fanconi syndromeActinsPhosphoric Monoester HydrolasesThiazolesBasic ResearchOculocerebrorenal SyndromeNephrology570 Life sciences; biology