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Cellular senescence and its association with aldose reductase promote cyst growth in autosomal dominant polycystic kidney disease

Kidney International(2025)10.1016/j.kint.2025.05.027Source: DataRank Database

Cellular senescence and its association with aldose reductase promote cyst growth in autosomal dominant polycystic kidney disease is a research paper published in Kidney International (2025). On theSindex it has a DataRank of 0. It has been cited 10 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access10 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 8.87)OA: closedTopics (62)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Lu Li ORCID,Geoffray Lee,Ewud Agborbesong,Julie Zhou ORCID,James P. Calvet ORCID

Live enrichment

PubMed:40578685 OpenAlex:https://openalex.org/W4411636476

U.S. Department of Defense

Grant: K01 DK107729

U.S. Department of Defense

Grant: PR221810

PKD Foundation

Grant: 1287624

National Institutes of Health

Grant: R01 DK129241

National Institutes of Health

Grant: R01 DK126662

FWCI

8.87

Citation Percentile

1.0%

Citation Trend

2025

2026

closedLicense: http://creativecommons.org/licenses/by-nc-nd/4.0/

publisherhttps://api.elsevier.com/content/article/PII:S0085253825004879?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0085253825004879?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.kint.2025.05.027

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40578685

Fields of Study

Genetic and Kidney Cyst DiseasesBiomedical Research and PathophysiologyRenal and related cancersAnimalsPolycystic Kidney, Autosomal DominantHumansCellular SenescenceMiceKidneyDisease Models, AnimalAldehyde ReductaseSenescence-Associated Secretory PhenotypeMice, TransgenicTRPP Cation ChannelsDasatinibSenotherapeuticsDisease ProgressionQuercetinMaleMutationCyclin-Dependent Kinase Inhibitor p16Cell Proliferation

MeSH Terms

DasatinibSenescence-Associated Secretory PhenotypeSenotherapeuticsAldehyde ReductaseAnimalsDisease Models, AnimalHumansKidneyMaleMice, TransgenicMutationQuercetinPolycystic Kidney, Autosomal DominantCellular SenescenceDisease ProgressionCyclin-Dependent Kinase Inhibitor p16Cell ProliferationTRPP Cation ChannelsMice

Keywords

Aldose reductaseAutosomal dominant polycystic kidney diseaseCystSenescenceDiseasePolycystic kidney diseaseInternal medicineEndocrinologyMedicinePolycystic kidneyKidney diseaseKidneyBiologyDiabetes mellitusPathologyCellular senescenceSASPAkr1b1AdpkdSenotherapeuticP16(ink4a)-positive Senescent Cells

Sustainable Development Goals

SDG 0: Zero hunger