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The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop

Mechanisms of Ageing and Development(2024)10.1016/j.mad.2024.111951Source: DataRank Database

The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop is a research paper published in Mechanisms of Ageing and Development (2024). On theSindex it has a DataRank of 0.368. It has been cited 10 times, with 4 citing works in its 1-hop citation network.

N/A

0.368DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access10 citations · 4 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE193327 GSE193403 GSE231710

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 4.52)OA: hybridTopics (52)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 98%Citation Network 2%

Base Score Contribution

0.360

From this paper's citation signal

Citation Network Contribution

7.96 × 10⁻³

From 1 citing papers with measurable signal

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Top 4 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 4 citers.

Heterozygous Hnf1a Mutation in Mice Reveals Multiple Pathogenic Mechanisms of HNF1A-MODY
Research Square20251 citations74 referencesContributes 0.009
Livers of hyperglycemic mice with Hnf1a-deficient pancreatic beta-cells show unexpected hepatic steatosis signs further exacerbated by high fat diet
Research Square20250 citations52 referencesContributes 0.000
Integrative proteomics and metabolomics analysis of the mechanism of pancreatic β-cell dysfunction in aged mice
Frontiers in Endocrinology20260 citations35 referencesContributes 0.000
Progressive HNF1A-MODY pathophysiology revealed by a translational mouse model
JCI Insight20260 citations62 referencesContributes 0.000

Authors (9)

Thomas Aga Legøy ORCID,Ulrik Larsen ORCID,Lucas Unger ORCID,Shadab Abadpour ORCID,Joao A. Paulo ORCID

Live enrichment

PubMed:38825059 OpenAlex:https://openalex.org/W4399269340

NIGMS

Grant: R01 GM132129

Novo Nordisk Fonden

Grant: NNF21OC0067325

Novo Nordisk Fonden

Grant: NNF15OC0015054

Norges Forskningsråd

Grant: NFR 247577

Norges Forskningsråd

Grant: 262613

Hybrid Technology Hub Senter for hybridteknologi

Norges Forskningsråd

Grant: 314397

Dissecting the role of islet non-ß populations’ identity maintenance in the development of monogenic diabetes

Norges Forskningsråd

Grant: 251041

Characterizing and modulating the insulin-producing beta-cell fate in monogenic diabetes by using novel genetic setups

Novo Nordisk Foundation

Grant: unidentified

unidentified

FWCI

4.52

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1016/j.mad.2024.111951

publisherhttps://doi.org/10.1016/j.mad.2024.111951

publisherhttps://api.elsevier.com/content/article/PII:S0047637424000514?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0047637424000514?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38825059

Fields of Study

Pancreatic function and diabetesGenetics and Neurodevelopmental DisordersEndoplasmic Reticulum Stress and Disease0301 basic medicine03 medical and health sciencesHepatocyte Nuclear Factor 1-alphaAnimalsIslets of LangerhansMiceHumansSignal TransductionAgingMice, Transgenic

MeSH Terms

AgingAnimalsHumansIslets of LangerhansMice, TransgenicSignal TransductionMiceHepatocyte Nuclear Factor 1-alpha

Keywords

BiologyIsletLongevityImmune systemTranscription factorTransgeneAgeingGenetically modified mouseCell biologyRegulatorPancreatic isletsKnockout mouseImmunologyGeneticsEndocrinologyInsulinReceptorGeneIslets of LangerhansMiceAgingAnimalsHumansMice, TransgenicHepatocyte Nuclear Factor 1-alphaArticleSignal TransductionHNF1AImmune responseIslet ageingPathway analysis

Related Papers (2)

Global proteomics reveals insulin abundance as a marker of human islet homeostasis alterations

N/A

0.360DataRank · unranked

Acta Physiologica(2023)

co-cited

10.1111/apha.14037

Unsupervised Clustering of Missense Variants in HNF1A Using Multidimensional Functional Data Aids Clinical Interpretation

The American Journal of Human Genetics(2020)

co-cited

10.1016/j.ajhg.2020.08.016