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Single-cell transcriptomics reveal a hyperacute cytokine and immune checkpoint axis after cardiac arrest in patients with poor neurological outcome

Med(2023)10.1016/j.medj.2023.05.003Source: DataRank Database

Single-cell transcriptomics reveal a hyperacute cytokine and immune checkpoint axis after cardiac arrest in patients with poor neurological outcome is a research paper published in Med (2023). On theSindex it has a DataRank of 0.458. It has been cited 12 times, with 8 citing works in its 1-hop citation network.

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0.458DataRank · unranked

Scored on demand from live citation data

Open Access12 citations · 8 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 4.10)OA: bronzeTopics (35)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 84%Citation Network 16%

Base Score Contribution

0.385

From this paper's citation signal

Citation Network Contribution

0.0733

From 4 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 8 citers.

Cardiac arrest triggers IL-17-mediated neuroinflammation and astrocyte polarization: insights into pathogenesis and intervention
Journal of Neuroinflammation20254 citations52 referencesContributes 0.031
Single-Cell Analysis in Cerebrovascular Research: Primed for Breakthroughs and Clinical Impact
Stroke20244 citations70 referencesContributes 0.023
Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies
Pharmaceuticals202569 citations198 referencesContributes 0.021
Mitochondrial DNA‐Mediated Immune Activation After Resuscitation From Cardiac Arrest
Journal of the American Heart Association20251 citations64 referencesContributes 0.011
The Identification of Key Genes and Biological Pathways in Cardiac Arrest by Integrated Bioinformatics and Next Generation Sequencing Data Analysis
bioRxiv (Cold Spring Harbor Laboratory)20240 citations1,373 referencesContributes 0.000

Authors (23)

Changde Cheng ORCID,Wenan Chen ORCID,Louis T. Merriam ORCID,Humra Athar,Y. Kim ORCID

Live enrichment

PubMed:37257452 OpenAlex:https://openalex.org/W4378952654

National Heart Lung and Blood Institute

Grant: R01HL166487

American Heart Association

Grant: 20TPA35500016

American Heart Association

Grant: 15FTF25080205

NCI NIH HHS

Grant: R01 CA262790

FWCI

4.10

Citation Percentile

0.9%

Citation Trend

2024

2025

2026

bronzeLicense: http://www.elsevier.com/open-access/userlicense/1.0/

journalhttp://www.cell.com/article/S2666634023001435/pdf

publisherhttp://www.cell.com/article/S2666634023001435/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2666634023001435?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2666634023001435?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.medj.2023.05.003

Fields of Study

Cardiac Arrest and ResuscitationCardiac Fibrosis and RemodelingImmune Cell Function and InteractionUnited StatesHumansFemaleCytokinesNectinsTranscriptomeKiller Cells, NaturalInflammation

MeSH Terms

NectinsFemaleHumansInflammationKiller Cells, NaturalUnited StatesCytokinesTranscriptome

Keywords

Immune systemInflammationMedicineCytokineImmunologyChemokineInnate immune systemNectin-2Translation to patientscardiac arrestimmune checkpointinterferon γmonocytenatural killer cellperipheral blood mononuclear cellssingle-cell RNA sequencing

Sustainable Development Goals

SDG 0: Good health and well-being