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Deficiency in indoleamine-2, 3-dioxygenase induces upregulation of guanylate binding protein 1 and inducible nitric oxide synthase expression in the brain during cerebral infection with Toxoplasma gondii in genetically resistant BALB/c mice but not in genetically susceptible C57BL/6 mice

Microbes and Infection(2021)10.1016/j.micinf.2021.104908Source: DataRank Database

Deficiency in indoleamine-2, 3-dioxygenase induces upregulation of guanylate binding protein 1 and inducible nitric oxide synthase expression in the brain during cerebral infection with Toxoplasma gondii in genetically resistant BALB/c mice but not in genetically susceptible C57BL/6 mice is a research paper published in Microbes and Infection (2021). On theSindex it has a DataRank of 0. It has been cited 26 times.

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Open Access26 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (13 grants)Impact (FWCI 1.89)OA: bronzeTopics (62)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)

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Findable (2/2)

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Accessible (1/2)

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Interoperable (2/2)

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Authors (6)

Jenny Lutshumba,Megan Whitlow,Mohamed Hamed Abdelaziz ORCID,Rajesh Mani ORCID,Yasuhiro Suzuki ORCID

Live enrichment

PubMed:34781010 PMC:PMC9081123 OpenAlex:https://openalex.org/W3213000722

National Institutes of Health

Grant: AI095032

National Institutes of Health

Grant: AI152597

National Institutes of Health

Grant: AI134323

National Institutes of Health

Grant: AI136821

National Institutes of Health

Grant: P30CA177558

NIAID NIH HHS

Grant: R01 AI095032

NIAID NIH HHS

Grant: R21 AI134323

NIAID NIH HHS

Grant: R56 AI152597

NIAID NIH HHS

Grant: R21 AI136821

National Institutes of Health

Grant: 1R21AI134323-01

Effector molecules for IFN-gamma-mediated prevention of Toxoplasma proliferation in the brain

National Institutes of Health

Grant: 1R56AI152597-01

Key sentinel roles of IFN-gamma production by microglia to orchestrate the innate and T cell-mediated protective immunity to prevent reactivation of cerebral Toxoplasma infection

National Institutes of Health

Grant: 5R21AI136821-02

Gender-dependent innate IL-10 production as a key pathogenic factor to promote toxoplasmic encephalitis

National Institutes of Health

Grant: 3P30CA177558-01S1

CTRP Supplement

FWCI

1.89

Citation Percentile

0.8%

Citation Trend

2022

2023

2024

2025

2026

bronzeLicense: Elsevier Non-Commercial

journalhttps://www.sciencedirect.com/science/article/pii/S1286457921001301/pdf

BRONZEhttps://www.sciencedirect.com/science/article/pii/S1286457921001301/pdf

publisherhttps://www.sciencedirect.com/science/article/pii/S1286457921001301/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1286457921001301?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1286457921001301?httpAccept=text/plain

Fields of Study

Toxoplasma gondii Research StudiesMedicineBiology0301 basic medicine03 medical and health sciences0302 clinical medicineAnimalsBrainDioxygenasesGenetic Predisposition to DiseaseIndoleamine-Pyrrole 2,3,-DioxygenaseMiceMice, Inbred BALB CMice, Inbred C57BLNitric Oxide Synthase Type IIToxoplasmaUp-Regulation

MeSH Terms

AnimalsBrainMice, Inbred BALB CMice, Inbred C57BLToxoplasmaUp-RegulationGenetic Predisposition to DiseaseDioxygenasesIndoleamine-Pyrrole 2,3,-DioxygenaseMiceNitric Oxide Synthase Type II

Keywords

Toxoplasma gondiiBiologyNitric oxide synthaseDownregulation and upregulationBALB/cEffectorIndoleamine 2,3-dioxygenaseMolecular biologyRatónGene expressionImmunologyVirologyNitric oxideAntibodyImmune systemGeneBiochemistryEndocrinologyProtective immunitygenetic resistanceNitric Oxide Synthase 2Guanylate Binding Protein 1Indoleamine-2,3-dioxigenaseMice, Inbred BALB CBrainNitric Oxide Synthase Type IIDioxygenasesUp-RegulationMice, Inbred C57BLMiceAnimalsIndoleamine-Pyrrole 2,3,-DioxygenaseGenetic Predisposition to DiseaseToxoplasma

Additional file 1 of The opposing effect of acute and chronic Toxoplasma gondii infection on tumor development

10.6084/m9.figshare.26729551.v1figshare

Additional file 1 of The opposing effect of acute and chronic Toxoplasma gondii infection on tumor development

10.6084/m9.figshare.26729551figshare