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Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ

Mitochondrion(2021)10.1016/j.mito.2021.09.010Source: DataRank Database

Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ is a research paper published in Mitochondrion (2021). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Open Access8 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)OA: greenTopics (28)IDs (PubMed)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Shalom Kim,Hyacintha‐ghislaine M. Bisimwa,Cody Grier,Md. Mostafijur Rahman ORCID,Carolyn K. J. Young ORCID

Live enrichment

PubMed:34619353

National Institutes of Health

Grant: P30 EY003039

National Institute of General Medical Sciences

Grant: R15GM139104

Fundação de Amparo à Pesquisa do Estado de São Paulo

Grant: 2017/04372-0

National Institute of Environmental Health Sciences

Grant: 5R00ES022638-04

The Roles of Polymerase Gamma Accessory Subunit Gene Mutations in Human Disease.

National Institutes of Health

Grant: 5P30EY003039-35

Vision Science Research Center

National Institutes of Health

Grant: 3R15GM139104-01A1S1

The Mechanism of Elimination of the Mitochondrial DNA Replisome

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8595818

publisherhttps://api.elsevier.com/content/article/PII:S1567724921001367?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1567724921001367?httpAccept=text/plain

repositoryhttp://hdl.handle.net/11449/229691

https://doi.org/10.1016/j.mito.2021.09.010

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

DNA ReplicationAntiviral nucleoside analoguespharmacology)CellsRemdesivirDNA, MitochondrialFibroblasts (metabolism)DNA polymerase gammaHumansCells, CulturedAlanine (analogs & derivativesCulturedAlanineSARS-CoV-2COVID-19 (metabolism)Adenosine Monophosphate (analogs & derivativesDNA Replication (drug effects)COVID-19DNAFibroblastsMitochondrial DNAAdenosine MonophosphateCOVID-19 Drug TreatmentDNA Polymerase gamma (metabolism)Mitochondrial (biosynthesis)

Sustainable Development Goals

SDG 3: 3. Good health