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Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

Molecular Cell(2021)10.1016/j.molcel.2021.04.028Source: DataRank Database

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease is a research paper published in Molecular Cell (2021). On theSindex it has a DataRank of 0. It has been cited 108 times.

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Open Access108 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (20 grants)Impact (FWCI 6.89)OA: hybridTopics (75)IDs (PubMed, PMC, OpenAlex)Annotations (5)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (20)

Thomas Agnew,Anne R. Wondisford,Michael Tellier ORCID,Nicole Kaminski ORCID,Danique Beijer ORCID

Live enrichment

PubMed:34019811 PMC:PMC8221567 OpenAlex:https://openalex.org/W3162472426

Cancer Research UK

Grant: S_4211

Wellcome Trust

Grant: 210634

Serine ADP-ribosylation in genome stability and human disease

Wellcome Trust

Grant: 210634/Z/18/Z

Novo Nordisk Foundation Center for Protein Research

Grant: PI Michael Lund Nielsen

Cancer Research UK

Grant: C35050/A22284

NCI NIH HHS

Grant: P30 CA047904

Medical Research Council

Grant: G0400653

Wellcome Trust

Grant: 203141/Z/16/Z

Wellcome Trust

Grant: 101794

Protein poly(ADP-ribosyl)ation in genome stability and human disease.

Wellcome Trust

Grant: 210641/Z/18/Z

Biotechnology and Biological Sciences Research Council

Grant: BB/R007195/1

Understanding the activity and role of DarTG, a toxin:antitoxin system responsible for a novel DNA modification

NCI NIH HHS

Grant: R01 CA207209

Cancer Research UK

Grant: 16304

Biotechnology and Biological Sciences Research Council

Grant: BB/R016836/1

The human pol II-transcribed snRNA genes; a model for gene-type specific transcription.

Cancer Research UK

Grant: 22284

Wellcome Trust

Grant: 203141

Human Genetics and Disease Biology: Core Renewal for the Wellcome Trust Centre for Human Genetics

European Commission

Grant: 779257

Solving the unsolved Rare Diseases

National Institutes of Health

Grant: 5R01CA207209-09

Inhibition of the ALT pathway by interfering with Poly-ADP-Ribose metabolism

National Institutes of Health

Grant: 3P30CA047904-07S1

CANCER CENTER SUPPORT GRANT

Wellcome Trust

FWCI

6.89

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.cell.com/article/S1097276521003579/pdf

publisherhttp://www.cell.com/article/S1097276521003579/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1097276521003579?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1097276521003579?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.molcel.2021.04.028

Fields of Study

PARP inhibition in cancer therapyDNA Repair MechanismsElectrostatic Discharge in Electronics0301 basic medicine0303 health sciences03 medical and health sciencesADP-RibosylationAdenosine Diphosphate RiboseCell Line, TumorChromatinDNADNA DamageFibroblastsGlycoside HydrolasesHEK293 CellsHeLa CellsHumansPoly ADP RibosylationPoly Adenosine Diphosphate RibosePrimary Cell Culture

MeSH Terms

ADP-RibosylationPoly ADP RibosylationAdenosine Diphosphate RiboseChromatinDNADNA DamageFibroblastsGlycoside HydrolasesHeLa CellsHumansPoly Adenosine Diphosphate RiboseCell Line, TumorHEK293 CellsPrimary Cell CultureHela Cells

Keywords

BiologyChromatinPARP1HistonePoly ADP ribose polymeraseCell biologyADP-ribosylationMitosisNeurodegenerationTranscription factorSerineGeneticsEnzymeBiochemistryDNADiseasePhosphorylationNAD+ kinaseGeneDNA damageCancerTelomereBrcaParp InhibitorPargArh3/adprhl2info:eu-repo/classification/ddc/570Adenosine Diphosphate RibosePoly Adenosine Diphosphate RiboseGlycoside HydrolasesPrimary Cell CultureFibroblastsArticleChemistryPoly ADP RibosylationHEK293 CellsCell Line, TumorHumansHuman medicineHeLa Cells

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being