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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1

Molecular Cell(2022)10.1016/j.molcel.2022.04.034Source: DataRank Database

ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1 is a research paper published in Molecular Cell (2022). On theSindex it has a DataRank of 0. It has been cited 23 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access23 citations

Cite:

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (23 grants)Impact (FWCI 1.57)OA: hybridTopics (48)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (27)

Radha Mukherjee,Rona Yaeger ORCID,Jieun Son ORCID,Jianing Xu ORCID,Na Na ORCID

Live enrichment

PubMed:35613620 OpenAlex:https://openalex.org/W4281388729

Lung Cancer Research Foundation

Grant: R35CA220497

Lung Cancer Research Foundation

Grant: R01 CA233736

Lung Cancer Research Foundation

Grant: U54 OD020355-01

Lung Cancer Research Foundation

Grant: R01 CA204749

Lung Cancer Research Foundation

Grant: R01 CA207244

Lung Cancer Research Foundation

Grant: U01 CA199215

Lung Cancer Research Foundation

Grant: R01 CA201247

Lung Cancer Research Foundation

Grant: P30 CA008748

Japan Agency for Medical Research and Development

Grant: 19cm0106513h0004

Japan Society for the Promotion of Science

Grant: 15KK0303

National Institutes of Health

Grant: P01 CA094060

National Institutes of Health

Grant: R35 CA210085

National Institutes of Health

Grant: 1R01CA201247-01A1

Origins of BRAF-mutant hematologic malignancies and their therapeutic resistance

National Institutes of Health

Grant: 5R35CA210085-06

Studies on oncoprotein-induced feedback: Basic and therapeutic implications

National Institutes of Health

Grant: 5R01CA204749-03

Understanding Long Tail Driver Mutations in Cancer

National Institutes of Health

Grant: 5U54OD020355-04

MSKCC Pilot Center for Precision Disease Modeling

National Institutes of Health

Grant: 2P30CA008748-43

MOUSE GENETICS

National Institutes of Health

Grant: 5P01CA094060-07

Mechanisms of Metastasis and Evasion of TGF-Beta Tumor Suppression Breast Cancer

National Institutes of Health

Grant: 5U01CA199215-02

Identification and validation of synthetic lethality in KRAS mutant lung adenocarcinoma patient derived xenografts

National Institutes of Health

Grant: 5R01CA207244-05

Targeting AKT-Mutant Human Cancers

National Institutes of Health

Grant: 5R35CA220497-03

Development of Combination Therapies to Delay/Prevent Acquired Drug Resistance

National Institutes of Health

Grant: 1R01CA233736-01

Exploiting the distinct genomics and signaling of colorectal cancers to effectively target ERK

NIH HHS

Grant: U54 OD020355

FWCI

1.57

Citation Percentile

0.8%

Citation Trend

2022

2023

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttp://www.cell.com/article/S1097276522004348/pdf

publisherhttp://www.cell.com/article/S1097276522004348/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1097276522004348?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1097276522004348?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.molcel.2022.04.034

Fields of Study

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase SignalingNF-κB Signaling Pathways0301 basic medicine0303 health sciences03 medical and health sciencesErbB ReceptorsGuanosine TriphosphateHumansNeurofibromin 1Protein BindingProto-Oncogene Proteins A-rafSignal Transductionras GTPase-Activating Proteins

MeSH Terms

Guanosine TriphosphateHumansProtein BindingSignal Transductionras GTPase-Activating ProteinsNeurofibromin 1Proto-Oncogene Proteins A-rafErbB Receptors

Keywords

BiologyCell biologyKinaseCancer research570Neurofibromin 1receptor tyrosine kinase inhibitor610Biological SciencesMedical and Health SciencesProto-Oncogene Proteins A-rafARAFErbB ReceptorsERK signalingRare DiseasesRAS-GTPNF1ras GTPase-Activating ProteinsHumansGuanosine Triphosphatedrug sensitivityLungCancerDevelopmental BiologyProtein BindingSignal Transduction

Sustainable Development Goals

SDG 0: Good health and well-being