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RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression

Molecular Cell(2023)10.1016/j.molcel.2023.08.029Source: DataRank Database

RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression is a research paper published in Molecular Cell (2023). On theSindex it has a DataRank of 0.747. It has been cited 23 times, with 19 citing works in its 1-hop citation network.

N/A

0.747DataRank · unranked

Scored on demand from live citation data

Open Access23 citations · 19 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (25 grants)Impact (FWCI 2.51)OA: hybridTopics (62)IDs (PubMed, PMC, OpenAlex)Annotations (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 64%Citation Network 36%

Base Score Contribution

0.477

From this paper's citation signal

Citation Network Contribution

0.270

From 12 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 19 citers.

Pulling rank with RNA: RANKL promotes the association of PGC-1β/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts
Molecular Cell20232 citations10 referencesContributes 0.110
Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis
Nature Metabolism202414 citations64 referencesContributes 0.042
The methyltransferase MLL4 promotes nonalcoholic steatohepatitis by enhancing NF-κB signaling
Journal of Biological Chemistry20247 citations69 referencesContributes 0.030
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions
GeroScience20248 citations84 referencesContributes 0.026
Histone hyperacetylation disrupts spermatogonial stem cells homeostasis and impairs spermiogenesis
Stem Cell Research & Therapy20252 citations47 referencesContributes 0.023

Authors (28)

Eric Kofman ORCID,Maria Almeida ORCID,Zhengyu Ouyang,Filipa Ponte ORCID,Jasmine R. Mueller ORCID

Live enrichment

PubMed:37751740 PMC:PMC10591845 OpenAlex:https://openalex.org/W4387026362

Fondation Leducq

Grant: S10 OD026929

Fondation Leducq

Grant: 16CVD01

Fondation Leducq

Grant: 10 OD026929

NIH

Grant: P20GM125503

NIH

Grant: DK063491

NIH

Grant: DK091183

NIH

Grant: AG068449

NIH

Grant: GM118060

NIH

Grant: GM085764

NIH

Grant: HL088083

NSF

Grant: DGE-2038238

Japan Society for the Promotion of Science

Grant: 201860150

NHLBI NIH HHS

Grant: P01 HL088093

NIGMS NIH HHS

Grant: R35 GM118060

NHLBI NIH HHS

Grant: P01 HL147835

NIA NIH HHS

Grant: R01 AG068449

NIDDK NIH HHS

Grant: R01 DK018477

NIDDK NIH HHS

Grant: R01 DK091183

NHLBI NIH HHS

Grant: R21 HL088083

NIDDK NIH HHS

Grant: R01 DK039949

NIDDK NIH HHS

Grant: P30 DK063491

NIGMS NIH HHS

Grant: P50 GM085764

National Science Foundation

Grant: 2038238

Graduate Research Fellowship Program (GRFP)

National Institutes of Health

Grant: 1S10OD026929-01

Illumina NovaSeq 6000 Sequencing System

National Institutes of Health

Grant: 5P20GM125503-04

Center for Musculoskeletal Disease Research (CMDR)

FWCI

2.51

Citation Percentile

0.9%

Influential Citations

Citation Trend

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://ars.els-cdn.com/content/image/1-s2.0-S1097276523006937-fx1_lrg.jpg

HYBRIDhttps://doi.org/10.1016/j.molcel.2023.08.029

publisherhttps://ars.els-cdn.com/content/image/1-s2.0-S1097276523006937-fx1_lrg.jpg

publisherhttps://api.elsevier.com/content/article/PII:S1097276523006937?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1097276523006937?httpAccept=text/plain

Fields of Study

NF-κB Signaling PathwaysBone Metabolism and DiseasesRNA Research and SplicingMedicineBiology0301 basic medicine03 medical and health sciences

MeSH Terms

Histone Deacetylase 3AnimalsHumansOsteoclastsRNAGene ExpressionMiceRANK LigandCo-Repressor ProteinsNuclear Receptor Co-Repressor 1

Keywords

HDAC3CorepressorBiologyRepressorActivator (genetics)Cell biologyRANKLNuclear receptor co-repressor 1HistoneHistone deacetylaseRegulation of gene expressionHDAC4Nuclear receptorTranscription factorGeneGeneticsOsteoclastNF-κBAP-1DeacetylationRanknon-coding RNAGene ExpressionCo-activatorH3k27acNcorPgc1β570Biomedical and clinical sciences1.1 Normal biological development and functioning610OsteoclastsMedical and Health SciencesHistone Deacetylase 3Mice2.1 Biological and endogenous factorsHumansAnimalsRANK LigandHealth sciencesBiological SciencesRNABiochemistry and Cell BiologyCo-Repressor ProteinsDevelopmental Biology