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High-throughput PRIME-editing screens identify functional DNA variants in the human genome

Molecular Cell(2023)10.1016/j.molcel.2023.11.021Source: DataRank Database

High-throughput PRIME-editing screens identify functional DNA variants in the human genome is a research paper published in Molecular Cell (2023). On theSindex it has a DataRank of 1.7. It has been cited 67 times, with 66 citing works in its 1-hop citation network.

N/A

1.7DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access67 citations · 66 citing works in its network

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Linked data & code

geo bioproject gen refsnp uniprot

Data availability

Repositories this paper deposited data in (declared in PubMed).

SRAPRJNA909251
BioProjectPRJNA909251

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (12 grants)Impact (FWCI 6.25)OA: hybridTopics (43)IDs (PubMed, PMC, OpenAlex)Annotations (5)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 38%Citation Network 62%

Base Score Contribution

0.633

From this paper's citation signal

Citation Network Contribution

1.0

From 52 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 66 citers.

Spatially Resolved Panoramic in vivo CRISPR Screen via Perturb-DBiT
Research Square202533 citations61 referencesContributes 0.058
High-throughput evaluation of genetic variants with prime editing sensor libraries
Nature Biotechnology202468 citations80 referencesContributes 0.053
Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput
Nature Methods202422 citations70 referencesContributes 0.045
High-throughput screening of human genetic variants by pooled prime editing
Cell Genomics202517 citations65 referencesContributes 0.044
A benchmarked, high-efficiency prime editing platform for multiplexed dropout screening
Nature Methods202433 citations80 referencesContributes 0.044

Authors (12)

Han Yang ORCID,Jovia L. Nierenberg ORCID,Yifan Sun ORCID,Jiawen Chen ORCID,Cooper Beaman ORCID

Live enrichment

PubMed:38134886 PMC:PMC10766087 OpenAlex:https://openalex.org/W4390063959

NEI NIH HHS

Grant: R01 EY027789

NIDA NIH HHS

Grant: U01 DA052713

NIA NIH HHS

Grant: R01 AG057497

NHGRI NIH HHS

Grant: UM1 HG009402

NHGRI NIH HHS

Grant: U01 HG011720

NIH HHS

Grant: S10 OD028511

National Institutes of Health

Grant: 1UM1HG009402-01

High throughput CRISPR-mediated functional validation of regulatory elements

National Institutes of Health

Grant: 1U01HG011720-01

Polygenic risk scores and health disparities: the role of blood cells immune response and evolutionary adaptation

National Institutes of Health

Grant: 1U01DA052713-01

Charting the 3D epigenome in human brain development and diseases

National Institutes of Health

Grant: 1S10OD028511-01

Illumina NovaSeq 6000 Sequencing System

National Institutes of Health

Grant: 5R01EY027789-05

Transcriptional regulation of BEST1 in retina pigment epithelium.

National Institutes of Health

Grant: 5R01AG057497-04

Functional characterization of Alzheimer's disease associated genetic variants

FWCI

6.25

Citation Percentile

1.0%

Influential Citations

Citation Trend

2023

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.cell.com/article/S1097276523009668/pdf

HYBRIDhttps://www.cell.com/article/S1097276523009668/pdf

publisherhttp://www.cell.com/article/S1097276523009668/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1097276523009668?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1097276523009668?httpAccept=text/plain

Fields of Study

CRISPR and Genetic EngineeringRNA and protein synthesis mechanismsRNA regulation and diseaseMedicineBiology0301 basic medicine03 medical and health sciences

MeSH Terms

Gene EditingDNAHumansRegulatory Sequences, Nucleic AcidReproducibility of ResultsGenome, HumanGenome-Wide Association StudyCRISPR-Cas Systems

Keywords

BiologyHuman genomeComputational biologyGeneticsGenomeDNAThroughputGenome editingPrime (order theory)GeneEnhancerHigh-throughput ScreensSingle-base ResolutionDisease VariantsPrime EditingGene Editing570Nucleic AcidGenome, Human610Reproducibility of ResultsRegulatory Sequences, Nucleic AcidArticleHumansCRISPR-Cas SystemsRegulatory SequencesHumanGenome-Wide Association Study

Sustainable Development Goals

SDG 0: Good health and well-being