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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

Molecular Cell(2024)10.1016/j.molcel.2024.04.026Source: DataRank Database

mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway is a research paper published in Molecular Cell (2024). On theSindex it has a DataRank of 0. It has been cited 45 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access45 citations

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Linked data & code

cellosaurus gen hpa

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)Impact (FWCI 7.47)OA: greenTopics (55)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Sara Sepic,Brenda A. Schulman ORCID,Alban Ordureau ORCID,Heeseon An ORCID,Sang Ah Yi ORCID

Live enrichment

PubMed:38788716 PMC:PMC11186538 OpenAlex:https://openalex.org/W4398234430

National Institutes of Health

Grant: R01GM152667

NCI NIH HHS

Grant: P30 CA008748

FWCI

7.47

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11186538/pdf/nihms-1993335.pdf

publisherhttps://api.elsevier.com/content/article/PII:S1097276524003939?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1097276524003939?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11186538

Fields of Study

Ubiquitin and proteasome pathwaysProtein Degradation and InhibitorsPI3K/AKT/mTOR signaling in cancerMechanistic Target of Rapamycin Complex 1HumansUbiquitin-Protein LigasesHEK293 CellsProteolysisHydroxymethylglutaryl-CoA SynthaseUbiquitinationCell ProliferationProteasome Endopeptidase ComplexTOR Serine-Threonine KinasesMevalonic AcidMultiprotein ComplexesSignal TransductionDegronsAdaptor Proteins, Signal Transducing

MeSH Terms

Mechanistic Target of Rapamycin Complex 1DegronsHumansHydroxymethylglutaryl-CoA SynthaseMevalonic AcidSignal TransductionUbiquitin-Protein LigasesMultiprotein ComplexesProteasome Endopeptidase ComplexAdaptor Proteins, Signal TransducingCell ProliferationUbiquitinationHEK293 CellsTOR Serine-Threonine KinasesProteolysis

Keywords

DegronBiologyUbiquitin ligaseDNA ligasemTORC1ATP synthaseCell biologyDegradation (telecommunications)Ubiquitin-Protein LigasesBiochemistryUbiquitinEnzymePhosphorylationGeneSterolubiquitin-proteasome systemMtorMevalonate PathwayGidDegradomicsHmgcs1Ctlh

Sustainable Development Goals

SDG 0: Clean water and sanitation

mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

FAIR Checklist

Authors (5)

Funding (2 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)