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Tuning insulin receptor signaling using de novo-designed agonists

Molecular Cell(2025)10.1016/j.molcel.2025.09.020Source: DataRank Database

Tuning insulin receptor signaling using de novo-designed agonists is a research paper published in Molecular Cell (2025). On theSindex it has a DataRank of 0. It has been cited 15 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access15 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)Impact (FWCI 6.09)OA: hybridTopics (47)IDs (PubMed, PMC, OpenAlex)Annotations (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (20)

Sarah Cardoso,Kaiyong Cai ORCID,Preetham Venkatesh ORCID,Albert Hung ORCID,Michelle Ng

Live enrichment

PubMed:41086805 PMC:PMC12702617 OpenAlex:https://openalex.org/W4415226693

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R01DK132361

National Institute of General Medical Sciences

Grant: R35GM142937

National Institute of General Medical Sciences

Grant: R35GM156386

Cancer Prevention and Research Institute of Texas

Grant: RP170644

Welch Foundation

Grant: I-1944

NIDDK NIH HHS

Grant: P30 DK132710

NIGMS NIH HHS

Grant: R35 GM157319

NIDDK NIH HHS

Grant: P30 DK063608

Irma T Hirschl Trust

National Institutes of Health

Open Philanthropy Project

Howard Hughes Medical Institute

Feldstein Medical Foundation

Audacious Project

FWCI

6.09

Citation Percentile

1.0%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1016/j.molcel.2025.09.020

publisherhttps://doi.org/10.1016/j.molcel.2025.09.020

publisherhttps://api.elsevier.com/content/article/PII:S1097276525007804?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1097276525007804?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41086805

Fields of Study

Receptor Mechanisms and SignalingPancreatic function and diabetesMetabolism, Diabetes, and CancerReceptor, InsulinHumansAnimalsCell ProliferationSignal TransductionInsulinMicePhosphorylationProto-Oncogene Proteins c-aktProtein ConformationHEK293 CellsHypoglycemic AgentsAntigens, CD

MeSH Terms

AnimalsHumansHypoglycemic AgentsInsulinPhosphorylationProtein ConformationReceptor, InsulinSignal TransductionAntigens, CDCell ProliferationProto-Oncogene Proteins c-aktMiceHEK293 Cells

Keywords

Insulin receptorIntracellularSignal transductionKinaseProtein kinase AExtracellularReceptorProtein kinase domainMAPK/ERK pathwayInsulinMetabolismCancerSignalingReceptor tyrosine kinaseDiabetesTraffickingComputational Protein DesignSevere Insulin-resistance Syndromes

Tuning insulin receptor signaling using de novo-designed agonists

FAIR Checklist

Authors (20)

Funding (14 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)