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Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism

Molecular Metabolism(2020)10.1016/j.molmet.2020.101039Source: DataRank Database

Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism is a research paper published in Molecular Metabolism (2020). On theSindex it has a DataRank of 0. It has been cited 19 times.

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Open Access19 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (7 grants)Impact (FWCI 0.78)OA: goldTopics (106)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Jae-Su Moon ORCID,Gautam Bandyopadhyay ORCID,Seo-Hee You,Kevin Lam ORCID,Xiao Liu ORCID

Live enrichment

PubMed:32534258 PMC:PMC7393408 OpenAlex:https://openalex.org/W3035059259

NIDDK NIH HHS

Grant: P30 DK063491

NIDDK NIH HHS

Grant: R01 DK124298

National Institutes of Health

Grant: 5R01DK124298-05

ANT2 in metaflammation and insulin resistance

National Institutes of Health

Grant: 3P30DK063491-04S1

Diabetes Endocrinology Research Center

Janssen Pharmaceuticals

University of California, San Diego

National Institute of Diabetes and Digestive and Kidney Diseases

FWCI

0.78

Citation Percentile

0.7%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://www.sciencedirect.com/science/article/pii/S2212877820301137/pdf

GOLDhttps://www.sciencedirect.com/science/article/pii/S2212877820301137/pdf

publisherhttps://www.sciencedirect.com/science/article/pii/S2212877820301137/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2212877820301137?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2212877820301137?httpAccept=text/plain

Fields of Study

Cancer, Hypoxia, and MetabolismHistone Deacetylase Inhibitors ResearchEicosanoids and Hypertension PharmacologyChemistryMedicine0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Endothelial PAS Domain-Containing Protein 1AnimalsGlucagonGlucoseHumansInsulinInsulin ResistanceLiverMaleMice, Inbred C57BLObesitySignal TransductionMice, KnockoutHepatocytesMiceBasic Helix-Loop-Helix ProteinsBasic Helix-Loop-Helix Transcription FactorsProlyl-Hydroxylase InhibitorsProlyl Hydroxylases

Keywords

Insulin sensitivityMechanism (biology)Internal medicineEndocrinologyGlucagonChemistryInsulinInsulin resistanceDiabetes mellitusSensitivity (control systems)Glucagon-like peptide-1MedicineType 2 diabetesLiver Glucagon SensitivityObesity-induced Glucose IntoleranceProlyl Hydroxylase Domain (Phd) EnzymesMaleInbred C57BL (mesh)PhysiologyInbred C57BLMiceInsulin Resistance (mesh)Basic Helix-Loop-Helix Transcription FactorsObesity (mesh)2.1 Biological and endogenous factorsAnimals (mesh)Liver Disease (rcdc)Male (mesh)3101 Biochemistry and cell biology (for-2020)Mice, KnockoutHumans (mesh)Insulin (mesh)Liver DiseaseDiabetesMice (mesh)Biological SciencesKnockout (mesh)Liver5.1 PharmaceuticalsEndothelial PAS Domain-Containing Protein 1Original ArticleProlyl Hydroxylases (mesh)Digestive Diseases (rcdc)Signal TransductionBasic Helix-Loop-Helix ProteinsLiver (mesh)1.1 Normal biological development and functioningKnockoutHepatocytes (mesh)0601 Biochemistry and Cell Biology (for)612Prolyl HydroxylasesProlyl-Hydroxylase Inhibitors (mesh)5.1 Pharmaceuticals (hrcs-rac)616Glucagon (mesh)AnimalsHumansObesityMetabolic and endocrineNutrition1.1 Normal biological development and functioning (hrcs-rac)Obesity (rcdc)31 Biological Sciences (for-2020)Prolyl-Hydroxylase Inhibitors2.1 Biological and endogenous factors (hrcs-rac)0606 Physiology (for)Glucose (mesh)RC31-1245Mice, Inbred C57BLNutrition (rcdc)Basic Helix-Loop-Helix Transcription Factors (mesh)GlucoseMetabolic and endocrine (hrcs-hc)HepatocytesDiabetes (rcdc)Signal Transduction (mesh)Biochemistry and Cell BiologyDigestive Diseases

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SDG 2: 2. Zero hungerSDG 3: 3. Good healthSDG 0: Good health and well-being