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Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

Molecular Metabolism(2025)10.1016/j.molmet.2025.102165Source: DataRank Database

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK is a research paper published in Molecular Metabolism (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (20 grants)Impact (FWCI 1.15)OA: goldTopics (50)IDs (PubMed, PMC, OpenAlex)Annotations (4)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

Michael D. Neinast ORCID,Ryo Kawakami ORCID,Nicholas Forelli,Cholsoon Jang ORCID,Jiten Patel ORCID

Live enrichment

PubMed:40348014 PMC:PMC12149413 OpenAlex:https://openalex.org/W4410193893

National Institutes of Health National Cancer Institute

Grant: 5T32CA257957

National Institutes of Health National Cancer Institute

Grant: CA248315

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: P30 DK019525

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: DK114103

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: DK109714

Sarnoff Cardiovascular Research Foundation

Grant: F31CA261041

National Heart Lung and Blood Institute Division of Intramural Research

Grant: T32-HL007843

National Institute of Food and Agriculture

Grant: NC1184

NHLBI NIH HHS

Grant: R01 HL152446

NCI NIH HHS

Grant: T32 CA257957

NCI NIH HHS

Grant: R01 CA248315

NIDDK NIH HHS

Grant: R01 DK114103

NIDDK NIH HHS

Grant: R01 DK109714

NHLBI NIH HHS

Grant: T32 HL007843

National Institutes of Health

Grant: 1T32CA257957-01

Post-doctoral Training Program in Cancer Metabolism and Tumor-host Interactions

National Institutes of Health

Grant: 5R01DK109714-09

Homeostatic Responses to Amino Acid Insufficiency

National Institutes of Health

Grant: 5P30DK019525-19

DIABETES ENDOCRINOLOGY RESEARCH CENTER

National Institutes of Health

Grant: 4T32HL007843-20

Training Program in Cardiovascular Biology and Medicine

National Institutes of Health

Grant: 1F31CA261041-01A1

The role of branched-chain amino acid metabolism and hyperinsulinemia in pancreatic cancer

National Institutes of Health

FWCI

1.15

Citation Percentile

0.8%

Citation Trend

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.molmet.2025.102165

publisherhttps://doi.org/10.1016/j.molmet.2025.102165

publisherhttps://api.elsevier.com/content/article/PII:S2212877825000729?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2212877825000729?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40348014

Fields of Study

Tryptophan and brain disordersAnimalsTryptophanMiceAmino Acids, Branched-ChainMice, KnockoutMaleMice, Inbred C57BLAllosteric RegulationOxidation-ReductionKynurenineProtein Kinases

MeSH Terms

Allosteric RegulationAmino Acids, Branched-ChainAnimalsKynurenineMaleMice, Inbred C57BLOxidation-ReductionProtein KinasesTryptophanMice, KnockoutMice

Keywords

Allosteric regulationChemistryTryptophanPharmacologyComputational biologyBiochemistryBiologyEnzymeAmino acidAlbuminBranched Chain Amino AcidBt2Tryptophan 2,3-DioxygenaseChild-centered CareBranched Chain Ketoacid Dehydrogenase KinaseMice, KnockoutMaleBrief CommunicationRC31-1245Mice, Inbred C57BLMiceAnimalsInternal medicineOxidation-ReductionProtein KinasesAmino Acids, Branched-ChainKynurenine

Sustainable Development Goals

SDG 0: Clean water and sanitation