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The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release

Molecular Pharmacology(2025)10.1016/j.molpha.2025.100059Source: DataRank Database

The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release is a research paper published in Molecular Pharmacology (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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0DataRank · unranked

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Open Access1 citations

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gen pdb

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 0.80)OA: bronzeTopics (34)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Tingzhen Shen,Alexander Vizurraga,Alexey Pronin ORCID,Taylor Henry,Qiang Wang ORCID

Live enrichment

PubMed:40706404 PMC:PMC12489383 OpenAlex:https://openalex.org/W4412043838

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R01DK126735

National Institute of General Medical Sciences

Grant: R35GM149539

National Institutes of Health

FWCI

0.80

Citation Percentile

0.7%

Citation Trend

2026

bronzeLicense: cc-by-nc-nd

journalhttps://molpharm.aspetjournals.org/article/S0026-895X(25)15319-4/pdf

publisherhttps://molpharm.aspetjournals.org/article/S0026-895X(25)15319-4/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0026895X25153194?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0026895X25153194?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.molpha.2025.100059

Fields of Study

Cell Adhesion Molecules ResearchReceptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

MeSH Terms

TroglitazoneAnimalsGuanosine DiphosphateHumansPeptides, CyclicProtein BindingSignal TransductionGTP-Binding Protein alpha Subunits, Gq-G11ThiazolidinedionesCell Line, TumorDepsipeptidesMiceHEK293 Cells

Keywords

TroglitazoneGq alpha subunitAlpha (finance)Protein subunitChemistryPharmacologyG alpha subunitInternal medicineEndocrinologyG proteinSignal transductionReceptorMedicineBiochemistryUveal MelanomaDrug RepurposingGuanine Nucleotide-binding Protein G(q) Subunit AlphaG Protein Inhibitor

Sustainable Development Goals

SDG 0: Decent work and economic growth

The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release

FAIR Checklist

Authors (11)

Funding (3 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)