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Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex

Molecular Pharmacology(2025)10.1016/j.molpha.2025.100075Source: DataRank Database

Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex is a research paper published in Molecular Pharmacology (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (14 grants)Impact (FWCI 0.42)OA: bronzeTopics (46)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Carolina Muguruza ORCID,Tomasz Maciej Stępniewski ORCID,Itziar Muneta‐Arrate ORCID,David Moreira,José Brea ORCID

Live enrichment

PubMed:41135363 PMC:PMC12799460 OpenAlex:https://openalex.org/W4415554276

Narodowym Centrum Nauki

Grant: 2017/27/N/NZ2/02571

Carlos III Health Institute

Grant: PI18/00094

Federación Española de Enfermedades Raras

Grant: SAF2017-88126R

Federación Española de Enfermedades Raras

Grant: SAF2009-08460

State Agency of Research

Grant: PID2019-106404RB-I00

Basque Government

Grant: IT-1512/22

Basque Government

Grant: KK-2019/00049

Basque Government

Grant: IT-1211/19

NIMH NIH HHS

Grant: R01 MH084894

European Commission

European Regional Development Fund

National Institutes of Health

Agència de Gestió d'Ajuts Universitaris i de Recerca

European Cooperation in Science and Technology

FWCI

0.42

Citation Percentile

0.6%

Citation Trend

2026

bronzeLicense: cc-by-nc-nd

journalhttps://molpharm.aspetjournals.org/article/S0026-895X(25)15635-6/pdf

publisherhttps://molpharm.aspetjournals.org/article/S0026-895X(25)15635-6/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0026895X25156356?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0026895X25156356?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.molpha.2025.100075

Fields of Study

Chemical Synthesis and AnalysisAmino Acid Enzymes and MetabolismProtein Structure and DynamicsHumansKetanserinReceptor, Serotonin, 5-HT2AAnimalsMalePrefrontal CortexLigandsFemaleMiceGTP-Binding ProteinsMolecular Dynamics SimulationSerotonin 5-HT2 Receptor AntagonistsGuanosine 5'-O-(3-Thiotriphosphate)Middle AgedAdult

MeSH Terms

AdultAnimalsFemaleHumansKetanserinLigandsMaleMiddle AgedGuanosine 5'-O-(3-Thiotriphosphate)Prefrontal CortexGTP-Binding ProteinsReceptor, Serotonin, 5-HT2AMiceMolecular Dynamics SimulationSerotonin 5-HT2 Receptor Antagonists

Keywords

KetanserinInverse agonistAgonistReceptorGTP'G proteinRadioligandBinding siteAntipsychoticInverse AgonismBiased AgonismFunctional Selectivity5-Ht(2a) Receptor

Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex

FAIR Checklist

Authors (12)

Funding (14 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)