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Molecular manipulation of the 1,5,6,7-tetrahydro-4H-indazol-4-one scaffold to obtain new human neutrophil elastase (HNE) inhibitors

Journal of Molecular Structure(2022)10.1016/j.molstruc.2022.133140Source: DataRank Database

Molecular manipulation of the 1,5,6,7-tetrahydro-4H-indazol-4-one scaffold to obtain new human neutrophil elastase (HNE) inhibitors is a research paper published in Journal of Molecular Structure (2022). On theSindex it has a DataRank of 0. It has been cited 4 times.

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0DataRank · unranked

Scored on demand from live citation data

4 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 0.34)OA: closedTopics (11)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (0/2)

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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Authors (13)

Letizia Crocetti ORCID,Gabriella Guerrini ORCID,Claudia Vergelli ORCID,Silvia Lamanna,Igor A. Schepetkin ORCID

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W4224314904

National Institutes of Health

Grant: GM115371

National Institutes of Health

Grant: GM103474

University of Florida Institute of Food and Agricultural Sciences

Grant: 1009546

FWCI

0.34

Citation Percentile

0.5%

Citation Trend

2023

2024

closedLicense: http://www.elsevier.com/open-access/userlicense/1.0/

publisherhttps://api.elsevier.com/content/article/PII:S0022286022008006?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0022286022008006?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.molstruc.2022.133140

repositoryhttp://hdl.handle.net/2158/1268057

Fields of Study

Protease and Inhibitor MechanismsS100 Proteins and AnnexinsBlood disorders and treatments

Keywords

ChemistryAcylationStereochemistryElastaseNeutrophil elastaseAlkylationEnzymeBiochemistry

Sustainable Development Goals

SDG 0: Good health and well-being

CCDC 2130023: Experimental Crystal Structure Determination

10.5517/ccdc.csd.cc29hgfqCambridge Crystallographic Data Centre

CCDC 2130022: Experimental Crystal Structure Determination

10.5517/ccdc.csd.cc29hgdpCambridge Crystallographic Data Centre

Molecular manipulation of the 1,5,6,7-tetrahydro-4H-indazol-4-one scaffold to obtain new human neutrophil elastase (HNE) inhibitors

FAIR Checklist

Authors (13)

Funding (3 grants)

Impact

Open Access

Topics

Linked Datasets (2)