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Pharmacokinetic and biodistribution (PK/BD) study of ProGel-Dex, a thermoresponsive dexamethasone prodrug for sustained joint pain relief in a mouse model of osteoarthritis

Nanomedicine Nanotechnology Biology and Medicine(2025)10.1016/j.nano.2025.102885Source: DataRank Database

Pharmacokinetic and biodistribution (PK/BD) study of ProGel-Dex, a thermoresponsive dexamethasone prodrug for sustained joint pain relief in a mouse model of osteoarthritis is a research paper published in Nanomedicine Nanotechnology Biology and Medicine (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (5 grants)Impact (FWCI 0.81)OA: greenTopics (33)IDs (PubMed, PMC, OpenAlex)Annotations (1)

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Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Gang Zhao ORCID,Xiaoke Xu,Zhenshan Jia ORCID,Devendra Kumar ORCID,Evan Glissmeyer

Live enrichment

PubMed:41352407 PMC:PMC13238187 OpenAlex:https://openalex.org/W4417013863

China Scholarship Council

Grant: 201707060010

National Institutes of Health

Grant: R44DA051278

National Institutes of Health

Grant: R01AR080500

N. Chen was supported by China Scholarship Council

FWCI

0.81

Citation Percentile

0.8%

Citation Trend

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13238187/

publisherhttps://api.elsevier.com/content/article/PII:S1549963425000863?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1549963425000863?httpAccept=text/plain

journalhttps://www.sciencedirect.com/science/article/pii/S1549963425000863/pdf

Fields of Study

Osteoarthritis Treatment and MechanismsPain Mechanisms and TreatmentsInflammatory mediators and NSAID effectsAnimalsOsteoarthritisMiceProdrugsTissue DistributionDexamethasoneDisease Models, AnimalArthralgiaMaleInjections, Intra-Articular

MeSH Terms

AnimalsDexamethasoneDisease Models, AnimalInjections, Intra-ArticularMaleOsteoarthritisProdrugsTissue DistributionArthralgiaMice

Keywords

OsteoarthritisBiodistributionPain reliefDexamethasoneJoint painPharmacokineticsArthritisProdrugThermoresponsive HydrogelPharmacokinetics And Biodistribution

Pharmacokinetic and biodistribution (PK/BD) study of ProGel-Dex, a thermoresponsive dexamethasone prodrug for sustained joint pain relief in a mouse model of osteoarthritis

FAIR Checklist

Authors (14)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)