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The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

Neurobiology of Disease(2020)10.1016/j.nbd.2020.105131Source: DataRank Database

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier is a research paper published in Neurobiology of Disease (2020). On theSindex it has a DataRank of 0. It has been cited 516 times.

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Open Access516 citations

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Enrichment:Funding (12 grants)OA: goldTopics (87)IDs (PubMed, PMC)Annotations (1)SDGs (1)

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Findable (1/2)

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Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Brandon J. DeOre ORCID,Abigail Baldwin‐Leclair,Trent A. Bullock,Hannah McGary,Jana A. Khan

Live enrichment

PubMed:33053430 PMC:PMC7547916

TPB

Grant: T32 DA007237

SHR & RP

Grant: 5R01DA046833

AMA

Grant: K01DA046308

NIH

Grant: 5R24HD000836

NIDA NIH HHS

Grant: R01 DA046833

NIDA NIH HHS

Grant: P30 DA013429

NICHD NIH HHS

Grant: R24 HD000836

National Institutes of Health

Grant: 1R01DA046833-01

Brain endothelial EVs role in the neuropathology of drugs of abuse and HIV

National Institutes of Health

Grant: 1K01DA046308-01A1

Role of Patrolling Monocytes in Cerebral Vascular Repair during HIV/Substance Abuse

National Institutes of Health

Grant: 5R24HD000836-54

Laboratory of Developmental Biology

National Institutes of Health

Grant: 5T32DA007237-29

Training Program: Drugs of Abuse & Related Neuropeptides

Eunice Kennedy Shriver National Institute of Child Health and Human Development

goldLicense: CC BY NC ND

publisherhttps://api.elsevier.com/content/article/PII:S096999612030406X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S096999612030406X?httpAccept=text/plain

Unpaywallhttps://doi.org/10.1016/j.nbd.2020.105131

Europe_PMChttps://europepmc.org/articles/PMC7547916

Europe_PMChttps://europepmc.org/articles/PMC7547916?pdf=render

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciencesAngiotensin-Converting Enzyme 2Blood-Brain BarrierCOVID-19Capillary PermeabilityCell Adhesion MoleculesCell SurvivalDementiaElectric ImpedanceEndothelial CellsFrontal LobeHumansHypertensionIn Vitro TechniquesInflammationIntercellular JunctionsInterleukin-6Lab-On-A-Chip DevicesMatrix MetalloproteinasesPrimary Cell CultureProtein DomainsProtein SubunitsRNA, MessengerSARS-CoV-2Spike Glycoprotein, Coronavirus

MeSH Terms

Blood-Brain BarrierFrontal LobeIntercellular JunctionsEndothelial CellsHumansDementiaHypertensionInflammationMatrix MetalloproteinasesCell Adhesion MoleculesProtein SubunitsRNA, MessengerInterleukin-6Cell SurvivalCapillary PermeabilityElectric ImpedanceLab-On-A-Chip DevicesPrimary Cell CultureSpike Glycoprotein, CoronavirusIn Vitro TechniquesProtein DomainsCOVID-19Angiotensin-Converting Enzyme 2SARS-CoV-2

Keywords

Tissue engineeringBlood-Brain Barrierneuroinflammationmicrofluidic chipCovid-19Sars-cov-2Cerebral Vascular BiologyCell SurvivalMessengerPrimary Cell CultureNeurosciences. Biological psychiatry. Neuropsychiatry612In Vitro TechniquesArticleCapillary PermeabilityProtein DomainsLab-On-A-Chip DevicesElectric ImpedanceHumansBiomedical Engineering and BioengineeringInflammationInterleukin-6Endothelial CellsSpike GlycoproteinMatrix MetalloproteinasesFrontal LobeCoronavirusProtein SubunitsIntercellular JunctionsNeurologyHypertensionRNADementiaAngiotensin-Converting Enzyme 2Cell Adhesion MoleculesRC321-571

Sustainable Development Goals

SDG 3: 3. Good health

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

FAIR Checklist

Authors (12)

Funding (12 grants)

Open Access

Topics

Annotations (Europe PMC)