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Identification of presenilin mutations that have sufficient gamma-secretase proteolytic activity to mediate Notch signaling but disrupt organelle and neuronal health

Neurobiology of Disease(2025)10.1016/j.nbd.2025.106961Source: DataRank Database

Identification of presenilin mutations that have sufficient gamma-secretase proteolytic activity to mediate Notch signaling but disrupt organelle and neuronal health is a research paper published in Neurobiology of Disease (2025). On theSindex it has a DataRank of 0. It has been cited 8 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access8 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 5.31)OA: goldTopics (35)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Kerry C. Ryan,Jocelyn T. Laboy,Ritika Patel,Brian Geller,Kenneth R. Norman ORCID

Live enrichment

PubMed:40404063 PMC:PMC12184874 OpenAlex:https://openalex.org/W4410512870

NIH National Institute of General Medical Sciences

Grant: GM145364

National Institute on Aging

Grant: AG064175

NIGMS NIH HHS

Grant: R35 GM145364

NIA NIH HHS

Grant: RF1 AG064175

NIH HHS

Grant: P40 OD010440

National Institutes of Health

FWCI

5.31

Citation Percentile

1.0%

Citation Trend

2025

2026

goldLicense: cc-by-nc

journalhttps://doi.org/10.1016/j.nbd.2025.106961

publisherhttps://doi.org/10.1016/j.nbd.2025.106961

publisherhttps://api.elsevier.com/content/article/PII:S0969996125001779?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0969996125001779?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40404063

Fields of Study

Alzheimer's disease research and treatmentsGenetics, Aging, and Longevity in Model OrganismsPrion Diseases and Protein Misfolding

MeSH Terms

AnimalsHumansMutationNeuronsOrganellesSignal TransductionCaenorhabditis elegansCaenorhabditis elegans ProteinsAnimals, Genetically ModifiedReceptors, NotchPresenilinsPresenilin-1Amyloid Precursor Protein SecretasesProteolysis

Keywords

PresenilinBiologyPSEN1Notch signaling pathwayGamma secretaseGeneticsMissense mutationMutationCell biologyCaenorhabditis elegansGeneAlzheimer's diseaseDiseaseMedicineMitochondriaCalciumLysosomesC. Elegans

Sustainable Development Goals

SDG 0: Zero hunger