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4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2–5 (Kv7.2-Kv7.5) channels

Neurobiology of Disease(2025)10.1016/j.nbd.2025.107252Source: DataRank Database

4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2–5 (Kv7.2-Kv7.5) channels is a research paper published in Neurobiology of Disease (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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Enrichment:Funding (11 grants)Impact (FWCI 0.39)OA: goldTopics (44)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Paige Hoffman,Christine R. Brzezinski,Brent R. O'Neill,Todd Hankinson ORCID,Charles C. Wilkinson

Live enrichment

PubMed:41456614 PMC:PMC12906913 OpenAlex:https://openalex.org/W7117362488

National Institute of Neurological Disorders and Stroke

Grant: NS086933

National Institute of Neurological Disorders and Stroke

Grant: 1K08NS131572-01A1

National Institute on Aging

Grant: AG83268

National Institute on Drug Abuse

Grant: DA017637

National Institutes of Health

Grant: HL149646

NHLBI NIH HHS

Grant: T32 HL149646

NINDS NIH HHS

Grant: K08 NS131572

NINDS NIH HHS

Grant: R01 NS086933

NIDA NIH HHS

Grant: T32 DA017637

NIA NIH HHS

Grant: R01 AG083268

American Epilepsy Society

FWCI

0.39

Citation Percentile

0.7%

Citation Trend

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.nbd.2025.107252

publisherhttps://doi.org/10.1016/j.nbd.2025.107252

publisherhttps://api.elsevier.com/content/article/PII:S0969996125004693?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0969996125004693?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41456614

Fields of Study

Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchNeurological disorders and treatmentsMedicineHumans4-AminopyridinePotassium Channel BlockersEpilepsyChildPyramidal CellsMaleFemaleKCNQ2 Potassium ChannelNeocortexNerve NetAction Potentials

MeSH Terms

Action PotentialsChildEpilepsyFemaleHumansMaleNerve Net4-AminopyridinePyramidal CellsNeocortexPotassium Channel BlockersKCNQ2 Potassium Channel

Keywords

BurstingPotassium channelAMPA receptorGABAergicInterneuronNMDA receptorEpilepsyGlutamate receptorExtracellularVoltage-dependent calcium channelGABADrug-resistant EpilepsyPediatric EpilepsyNetwork OscillationsHuman Brain TissueM-current

Sustainable Development Goals

SDG 0: Good health and well-being

4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2–5 (Kv7.2-Kv7.5) channels

FAIR Checklist

Authors (9)

Funding (11 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)