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P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9

Neoplasia(2021)10.1016/j.neo.2021.01.004Source: DataRank Database

P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9 is a research paper published in Neoplasia (2021). On theSindex it has a DataRank of 0. It has been cited 28 times.

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Open Access28 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)OA: goldTopics (50)IDs (PubMed, PMC)SDGs (1)

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Accessible (1/2)

Open Access

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Authors (8)

Nagib Ahsan ORCID,Amriti R. Lulla ORCID,Avital Lev ORCID,Philip H. Abbosh ORCID,David T. Dicker ORCID

Live enrichment

PubMed:33582407 PMC:PMC7890376

National Cancer Institute

Grant: CA176289

National Institutes of Health

Grant: 5R01CA176289-03

Targeting the oncogenic mutant p53 signaling in colorectal cancer therapy

American Cancer Society

American Cyronics Society

National Institutes of Health

goldLicense: cc-by-nc-nd

publisherhttps://www.sciencedirect.com/science/article/pii/S1476558621000051/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1476558621000051?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1476558621000051?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7890376

repositoryhttps://doaj.org/article/f248dc97de074030a6ab9d54d66559a8

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Cell Line, TumorHumansInhibitory Concentration 50Signal TransductionApoptosisCell SurvivalMAP Kinase Signaling SystemGene Expression Regulation, NeoplasticMutationGenes, mycModels, BiologicalTumor Suppressor Protein p53Cyclin-Dependent Kinase 9Activating Transcription Factor 4Endoplasmic Reticulum StressCRISPR-Cas SystemsGene Editing

Keywords

Cancer therapyMYCERK1/2CDK9PumaMutant p53DR5ATF4P53 Pathway RestorationPg3-ocCell SurvivalMAP Kinase Signaling SystemGenes, mycApoptosisModels, BiologicalInhibitory Concentration 50Cell Line, TumorHumansRC254-282Original ResearchGene EditingNeoplasms. Tumors. Oncology. Including cancer and carcinogensEndoplasmic Reticulum StressActivating Transcription Factor 4Cyclin-Dependent Kinase 9Gene Expression Regulation, NeoplasticMutationCRISPR-Cas SystemsTumor Suppressor Protein p53Signal Transduction

Sustainable Development Goals

SDG 3: 3. Good health