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The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53

Neoplasia(2021)10.1016/j.neo.2021.05.003Source: DataRank Database

The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53 is a research paper published in Neoplasia (2021). On theSindex it has a DataRank of 0.416. It has been cited 15 times.

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0.416DataRank · unranked

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Open Access15 citations

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Enrichment:Funding (19 grants)OA: goldTopics (86)IDs (PubMed, PMC)Annotations (3)SDGs (1)

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Accessible (1/2)

Open Access

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Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.416

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Authors (17)

Oscar Sias‐Garcia,Nicole Nasholm ORCID,Xiaoyu Hu ORCID,Amanda Balboni Iniguez ORCID,Matthew D. Hall ORCID

Live enrichment

PubMed:34107377 PMC:PMC8192452

National Institutes of Health

Grant: K08NS079485

National Institutes of Health

Grant: P01CA217959

National Institutes of Health

Grant: P30CA082103

National Institutes of Health

Grant: R01NS088355

U.S. Department of Defense

Grant: W81XWH-15-1-0166

Baylor College of Medicine

Grant: P30 CA125123

National Institute of Allergy and Infectious Diseases

Grant: P30AI036211

National Center for Research Resources

Grant: S10RR024574

NCI NIH HHS

Grant: T32 CA128583

National Institutes of Health

Grant: 1S10RR024574-01A1

BD Biosciences Special Order LSRII

National Institutes of Health

Grant: 3P30CA082103-21S2

Cancer Center Support Grant

National Institutes of Health

Grant: 7P01CA217959-04

Discovering and Exploiting Mechanisms of Neuroblastoma Therapy Resistance

National Institutes of Health

Grant: 3P30CA125123-09S3

Baylor College of Medicine Cancer Center

National Institutes of Health

Grant: 5R01NS088355-03

Targeting BET-bromodomains in neuroblastoma

National Institutes of Health

Grant: 1K08NS079485-01

Blockade of p53 and Aurora A in Therapy Resistant Neuroblastoma

National Institutes of Health

Grant: 5P30AI036211-05

CORE--VIROLOGY

Alex's Lemonade Stand Foundation for Childhood Cancer

Hyundai Hope On Wheels

National Center for Advancing Translational Sciences

goldLicense: cc-by-nc-nd

publisherhttps://doi.org/10.1016/j.neo.2021.05.003

publisherhttps://api.elsevier.com/content/article/PII:S1476558621000282?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1476558621000282?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8192452

repositoryhttps://doaj.org/article/e7ee05c4dfde46b7a9eedd9150ea3b8c

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Cell Line, TumorAnimalsHumansMiceNeuroblastomaProteinsProtein Kinase InhibitorsImmunohistochemistryXenograft Model Antitumor AssaysApoptosisCell ProliferationCell SurvivalGene AmplificationGene Expression Regulation, NeoplasticTumor Suppressor Protein p53Aurora Kinase AN-Myc Proto-Oncogene ProteinGene EditingBromodomain Containing Proteins

Keywords

ApoptosisNeuroblastomasynergyTp53MycnMedical SciencesClinical sciencesNBLBETiMiceBromodomain Containing Proteinsaurora kinaseMedical SpecialtiesMedicine and Health SciencesMechanism Interrogation PlatERC254-282Biological PhenomenaCancerOriginal ResearchAurora Kinase APediatricGene EditingN-Myc Proto-Oncogene ProteinTumorCell PhenomenaAURKAiNeoplasms. Tumors. Oncology. Including cancer and carcinogens600ImmunohistochemistryGene Expression Regulation, NeoplasticNeurologyOncology5.1 PharmaceuticalsPediatric CancerCell SurvivalAURKOncology and CarcinogenesisNeurosurgery610Medical BiochemistryBiomedical InformaticsCell LineRare DiseasesClinical ResearchCell Line, TumorGeneticsand ImmunityAnimalsHumansOncology & CarcinogenesisProtein Kinase InhibitorsCell Proliferationaurora A kinase inhibitor(s)NeoplasticBiomedical and Clinical SciencesNeurosciencesGene AmplificationProteinsMIPEXenograft Model Antitumor AssaysOrphan DrugGene Expression RegulationBET bromodomain inhibitor(s)Tumor Suppressor Protein p53

Sustainable Development Goals

SDG 3: 3. Good health