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The FDA-approved compound, pramipexole and the clinical-stage investigational drug, dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture

Neuroscience Letters(2023)10.1016/j.neulet.2023.137419Source: DataRank Database

The FDA-approved compound, pramipexole and the clinical-stage investigational drug, dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture is a research paper published in Neuroscience Letters (2023). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Enrichment:Funding (12 grants)OA: hybridTopics (36)IDs (PubMed, PMC)Annotations (1)

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Authors (11)

Shahani Noor ORCID,Melody S. Sun ORCID,Justine R Zimmerly,Andrea A Pasmay,Jóse Javier Sánchez ORCID

Live enrichment

PubMed:37558176 PMC:PMC10552878

National Institute on Alcohol Abuse and Alcoholism

Grant: T32-AA014127

National Institute on Alcohol Abuse and Alcoholism

Grant: P50-AA022534

National Institute on Alcohol Abuse and Alcoholism

Grant: R21-AA023051

National Institute on Alcohol Abuse and Alcoholism

Grant: R01-AA025967

National Center for Advancing Translational Sciences

Grant: 5UL1TR001449

NCATS NIH HHS

Grant: UL1 TR001449

NIDA NIH HHS

Grant: R01 DA018156

NIAAA NIH HHS

Grant: P50 AA022534

NIAAA NIH HHS

Grant: T32 AA014127

NIAAA NIH HHS

Grant: R01 AA025967

NIAAA NIH HHS

Grant: R21 AA023051

National Institutes of Health

hybridLicense: cc-by-nc-nd

publisherhttps://doi.org/10.1016/j.neulet.2023.137419

publisherhttps://api.elsevier.com/content/article/PII:S0304394023003786?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0304394023003786?httpAccept=text/plain

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10552878/pdf/nihms-1927492.pdf

Fields of Study

MiceRatsHumansAnimalsInterleukin-10HyperalgesiaPramipexoleDrugs, InvestigationalCytokinesNeuralgiaSciatic NeuropathySpinal CordSciatic NervePeripheral Nerve InjuriesCell Culture Techniques

MeSH Terms

Spinal CordSciatic NerveAnimalsHumansMiceRatsNeuralgiaHyperalgesiaSciatic NeuropathyInterleukin-10CytokinesDrugs, InvestigationalCell Culture TechniquesPeripheral Nerve InjuriesPramipexole

Keywords

Neuropathic painIL-10IL-1 βNeuroimmunePramipexoleDexpramipexole