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An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

Neurobiology of Aging(2020)10.1016/j.neurobiolaging.2020.06.023Source: DataRank Database

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene is a research paper published in Neurobiology of Aging (2020). On theSindex it has a DataRank of 0.688. It has been cited 97 times.

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Open Access97 citations

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Enrichment:Funding (21 grants)OA: hybridTopics (50)Linked Datasets (22)DataCite Reuse (22)IDs (PubMed, PMC)Annotations (2)SDGs (1)

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Base Score 100%Citation Network 0%

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0.688

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Authors (22)

Adam R. Smith ORCID,Rebecca G. Smith ORCID,Ehsan Pishva ORCID,Zina Ibrahim ORCID,Martina Sattlecker

Live enrichment

PubMed:32745807 PMC:PMC7649340

Medical Research Council

Grant: HDR-9003

Medical Research Council

Grant: HDR-9004

Alzheimer's Society

Grant: 14

Medical Research Council

Grant: MR/N027973/1

JPND: Targeting epigenetic dysregulation in the brainstem in Alzheimer's Disease (EPI-AD)

Medical Research Council

Grant: 1790286

Medical Research Council

Grant: MC_PC_17214

Medical Research Council

Grant: HDR-2007

NIA NIH HHS

Grant: R01 AG036039

Medical Research Council

Grant: HDR-9002

National Institutes of Health

Grant: 5R01AG036039-02

A multi-faceted approach to epigenomic profiling in Alzheimer's disorder

European Commission

Grant: 643417

ERA-NET for establishing synergies between the Joint Programming on Neurodegenerative Diseases Research and Horizon 2020

Wellcome Trust

Grant: unidentified

unidentified

British Heart Foundation

EU Joint Programme – Neurodegenerative Disease Research

National Institute for Health Research (NIHR)

Wellcome Trust

Alzheimer’s Research UK

Alzheimer's Society

Chief Scientist Office

National Institutes of Health

Medical Research Council

hybridLicense: cc-by

publisherhttps://doi.org/10.1016/j.neurobiolaging.2020.06.023

publisherhttps://api.elsevier.com/content/article/PII:S0197458020302165?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0197458020302165?httpAccept=text/plain

repositoryhttps://cris.maastrichtuniversity.nl/en/publications/1ac0f82a-e5ec-4d75-a961-188d4779c247

repositoryhttps://hal.science/hal-04538797v1/document

Fields of Study

03 medical and health sciences0302 clinical medicine

MeSH Terms

BrainHumansAlzheimer DiseaseApolipoproteins EHomeodomain ProteinsDNA MethylationGenotypeAgedAged, 80 and overFemaleMaleGenome-Wide Association StudyCognitive Dysfunction

Keywords

BloodDNA methylationBiomarkerAlzheimer's disease (AD)Mild Cognitive Impairment (Mci)Hoxb6MaleMILD COGNITIVE IMPAIRMENTGenotypeBIOMARKERSAlzheimer’s disease (AD)610Apolipoproteins EAlzheimer Disease616HumansCognitive DysfunctionALGORITHMMESSENGER-RNA EXPRESSIONAgedRISKAged, 80 and overHomeodomain ProteinsDEMENTIAMETHYLATIONBrainRegular ArticleAlzheimer's diseaseOXYTOCINPATTERN[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologieDISCOVERYFemalePACKAGEGenome-Wide Association Study

Sustainable Development Goals

SDG 3: 3. Good health

Additional file 1 of Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regions

10.6084/m9.figshare.13107633.v1figshare

Additional file 1 of Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regions

10.6084/m9.figshare.13107633figshare

Additional file 1 of Association of peripheral blood DNA methylation level with Alzheimer’s disease progression

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Additional file 1 of Association of peripheral blood DNA methylation level with Alzheimer’s disease progression

10.6084/m9.figshare.16821479figshare

Additional file 1 of Blood-based epigenome-wide analyses of cognitive abilities

10.6084/m9.figshare.18585799.v1figshare

Additional file 1 of Blood-based epigenome-wide analyses of cognitive abilities

10.6084/m9.figshare.18585799figshare

Additional file 2 of Blood-based epigenome-wide analyses of cognitive abilities

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Additional file 2 of Blood-based epigenome-wide analyses of cognitive abilities

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Additional file 3 of Blood-based epigenome-wide analyses of cognitive abilities

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Additional file 3 of Blood-based epigenome-wide analyses of cognitive abilities

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Additional file 4 of Blood-based epigenome-wide analyses of cognitive abilities

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Additional file 4 of Blood-based epigenome-wide analyses of cognitive abilities

10.6084/m9.figshare.18585808figshare

Additional file 1 of Distinct sex-specific DNA methylation differences in Alzheimer’s disease

10.6084/m9.figshare.21129953.v1figshare

Additional file 1 of Distinct sex-specific DNA methylation differences in Alzheimer’s disease

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Additional file 1 of Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control

10.6084/m9.figshare.22610218.v1figshare

Additional file 1 of Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control

10.6084/m9.figshare.22610218figshare

Additional file 2 of Distinct sex-specific DNA methylation differences in Alzheimer’s disease

10.6084/m9.figshare.21129954.v1figshare

Additional file 2 of Distinct sex-specific DNA methylation differences in Alzheimer’s disease

10.6084/m9.figshare.21129954figshare

Additional file 2 of Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control

10.6084/m9.figshare.22610221figshare

Additional file 2 of Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control

10.6084/m9.figshare.22610221.v1figshare