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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease

Neuron(2022)10.1016/j.neuron.2022.05.009Source: DataRank Database

Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease is a research paper published in Neuron (2022). On theSindex it has a DataRank of 0. It has been cited 206 times.

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Open Access206 citations

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Enrichment:Funding (30 grants)Impact (FWCI 13.20)OA: greenTopics (50)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (19)

Tae‐In Kam ORCID,Hu Wang ORCID,Stewart Neifert ORCID,Shih-Ching Chou,Manoj Kumar ORCID

Live enrichment

PubMed:35654037 PMC:PMC9357148 OpenAlex:https://openalex.org/W4281959735

NIGMS

Grant: T32GM136577

NIA

Grant: F30AG067643

Parkinson's Disease Foundation Inc

Grant: PF-JFA-1933

Diana Helis Henry Medical Research Foundation Inc

Grant: H-2014

Maryland Stem Cell Research Fund

Grant: 2019-MSCRFD-4292

Maryland Stem Cell Research Fund

Grant: 2017-MSCRFF-3838

NINDS

Grant: NS38377

NINDS

Grant: P30 NS050274

NINDS NIH HHS

Grant: P50 NS038377

NINDS NIH HHS

Grant: R01 NS107318

NIA NIH HHS

Grant: R01 AG073291

NIA NIH HHS

Grant: P30 AG066507

NIA NIH HHS

Grant: K01 AG056841

NIA NIH HHS

Grant: K99 AG066862

NINDS NIH HHS

Grant: T32 NS091018

National Institutes of Health

Grant: 2T32GM136577-06

Medical Scientist Training Program

National Institutes of Health

Grant: 5P30NS050274-14

JHU Center for Neuroscience Research

National Institutes of Health

Grant: 5K01AG056841-02

Influence of Aging on Pathogenic Alpha-Synuclein Strains and Transmission Mechanism

National Institutes of Health

Grant: 5P50NS038377-03

CORE--TRANSGENIC AND NEUROBEHAVIOR FACILITY

National Institutes of Health

Grant: 5R01NS107318-05

Understanding the Mechanism of Pathological alpha-Synuclein Transmission

National Institutes of Health

Grant: 5K99AG066862-02

ASC oligomerization and transmission as an initiating event for protein aggregation in Synucleinopathy Dementias

National Institutes of Health

Grant: 5F30AG067643-03

Astrocyte NLRP3 inflammasome activation in Parkinson's disease

Adrienne Helis Malvin Medical Research Foundation

Israel National Road Safety Authority

JPB Foundation

National Institutes of Health

Johns Hopkins Hospital

Johns Hopkins University

School of Medicine, Johns Hopkins University

Parkinson's Foundation

FWCI

13.20

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

greenLicense: Elsevier Non-Commercial

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9357148

publisherhttps://api.elsevier.com/content/article/PII:S0896627322004500?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0896627322004500?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.neuron.2022.05.009

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsAdenosine and Purinergic SignalingInflammasome and immune disorders03 medical and health sciences0302 clinical medicine

MeSH Terms

NLR ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsHumansParkinson DiseaseRepressor ProteinsUbiquitin-Protein LigasesMiceInflammasomesDopaminergic Neurons

Keywords

ParkinInflammasomePars compactaNeurodegenerationSubstantia nigraNeuroscienceParkinson's diseaseCell biologyUbiquitin ligaseUbiquitinBiologyDopamineChemistryReceptorMedicineDiseaseBiochemistryDopaminergicInternal medicineUbiquitinationParisParkinson’s Diseasecaspase-1Nlrp3Znf746Repressor ProteinsMiceInflammasomesDopaminergic NeuronsUbiquitin-Protein LigasesNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsHumansNLR ProteinsParkinson Disease

Sustainable Development Goals

SDG 0: Good health and well-being

Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease

FAIR Checklist

Authors (19)

Funding (30 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)