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Site-Directed Mutagenesis Improves the Transduction Efficiency of Capsid Library-Derived Recombinant AAV Vectors

Molecular Therapy — Methods & Clinical Development(2020)10.1016/j.omtm.2020.03.007Source: DataRank Database

Site-Directed Mutagenesis Improves the Transduction Efficiency of Capsid Library-Derived Recombinant AAV Vectors is a research paper published in Molecular Therapy — Methods & Clinical Development (2020). On theSindex it has a DataRank of 1.1. It has been cited 28 times, with 22 citing works in its 1-hop citation network.

N/A

1.1DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access28 citations · 22 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

ClinicalTrials.govNCT03003533

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (16 grants)OA: goldTopics (16)IDs (PubMed)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 45%Citation Network 55%

Base Score Contribution

0.505

From this paper's citation signal

Citation Network Contribution

0.612

From 19 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 22 citers.

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Scientific Reports202327 citations33 referencesContributes 0.101
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Human Gene Therapy20254 citations25 referencesContributes 0.064
Prediction of Adeno-Associated Virus Fitness with a Protein Language Based Machine Learning Model
bioRxiv (Cold Spring Harbor Laboratory)20243 citations22 referencesContributes 0.063
Reactive oxygen species enhance rAAV transduction by promoting its escape from late endosomes
Virology Journal20238 citations37 referencesContributes 0.059
Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity
Molecular Therapy — Methods & Clinical Development202026 citations59 referencesContributes 0.056

Authors (12)

X Chen ORCID,Yilin Xie ORCID,Qingyun Zheng,Jinyan Xie ORCID,Chenghui Yu

Live enrichment

PubMed:32258217

Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning

Grant: TP2016004

National Institutes of Health

Grant: R01 GM082946

U.S. Public Health Service

Grant: R01 HL-097088

U.S. Public Health Service

Grant: R21 EB-015684

U.S. Public Health Service

Grant: R41 AI-122735

Natural Science Foundation of Shanghai

Grant: 17ZR1448400

National Institutes of Health

Grant: 1R01HL097088-01A2

Next Generation of Recombinant AAV Serotype Vectors for Gene Therapy

National Institutes of Health

Grant: 1R21EB015684-01

Safety and efficacy of optimized AAV3 vectors in murine and NHP livers

National Institutes of Health

Grant: 1R41AI122735-01

Development of Optimized AAV Serotype Vectors for Human Gene Therapy

National Institutes of Health

Grant: 2R01GM082946-06A1

AAV capsids and their cellular interactions

NIGMS NIH HHS

Grant: R01 GM119186

NHLBI NIH HHS

Grant: R01 HL097088

NIAID NIH HHS

Grant: R21 AI131328

NIBIB NIH HHS

Grant: R21 EB015684

NIAID NIH HHS

Grant: R41 AI122735

NIGMS NIH HHS

Grant: K12 GM000678

goldLicense: cc-by

publisherhttp://www.cell.com/article/S2329050120300371/pdf

publisherhttps://api.elsevier.com/content/article/PII:S2329050120300371?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2329050120300371?httpAccept=text/plain

repositoryhttps://doaj.org/article/b38a05093c5a4598a4a393131cc871b5

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7114622

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

QH573-671transduction efficiencyvector distributionQH426-470rAAV vectorgene therapyArticlelibrary selectionGeneticssite-directed mutagenesisCytologycancer targetinghepatocellular carcinoma

Sustainable Development Goals

SDG 3: 3. Good health

Related Papers (1)

Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features

Top 7%

3.1DataRank

Viruses(2021)

co-cited

10.3390/v13010101