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Efficient manufacturing and engraftment of CCR5 gene-edited HSPCs following busulfan conditioning in nonhuman primates

Molecular Therapy — Methods & Clinical Development(2023)10.1016/j.omtm.2023.07.006Source: DataRank Database

Efficient manufacturing and engraftment of CCR5 gene-edited HSPCs following busulfan conditioning in nonhuman primates is a research paper published in Molecular Therapy — Methods & Clinical Development (2023). On theSindex it has a DataRank of 0.408. It has been cited 6 times, with 2 citing works in its 1-hop citation network.

N/A

0.408DataRank · unranked

Scored on demand from live citation data

Open Access6 citations · 2 citing works in its network

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Linked data & code

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)OA: goldTopics (29)IDs (PubMed, PMC)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 72%Citation Network 28%

Base Score Contribution

0.292

From this paper's citation signal

Citation Network Contribution

0.116

From 2 citing papers with measurable signal

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Top 2 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 2 citers.

Toward effective hematopoietic stem cell gene therapies: Optimized conditioning regimen and stem cell source in harmony
Molecular Therapy — Methods & Clinical Development20233 citations11 referencesContributes 0.126
In vivo HSC gene therapy enables sustained eCD4-Ig expression for SIV prevention
Molecular Therapy Advances20261 citations67 referencesContributes 0.010

Authors (9)

Teresa Einhaus,Rasika Venkataraman ORCID,Stefan Radtke ORCID,Anjie Zhen ORCID,Mayra A. Carrillo ORCID

Live enrichment

PubMed:37575091 PMC:PMC10415663

NIH HHS

Grant: U42 OD011123

NIAID NIH HHS

Grant: U19 AI149504

NIAID NIH HHS

Grant: R01 AI135953

NIAID NIH HHS

Grant: R01 AI167004

NHLBI NIH HHS

Grant: U19 HL156247

NIH HHS

Grant: P51 OD010425

NIAID NIH HHS

Grant: R01 AI170214

National Institutes of Health

Grant: 5U19AI149504-03

(Attack)2: Genetic engineering of cellular and humoral immunity to cure HIV

National Institutes of Health

Grant: 1R01AI135953-01

Targeting a Novel Hematopoietic Stem Cell Population in Non-Human Primates for Effective and Sustained Gene Therapy

National Institutes of Health

Grant: 5R01AI170214-03

Developing Durable, Env-Boosted CAR T Cells for HIV Cure

National Institutes of Health

Grant: 5R01AI167004-03

In Vivo Gene Editing of B cells with NICE-AAV Vectors

National Institutes of Health

Grant: 3P51OD010425-53S1

Washington National Primate Research Center

National Institutes of Health

Grant: 2U42OD011123-10

WaNPRC Macaca nemestrina SPF Breeding Colony

National Institutes of Health

Grant: 1U19HL156247-01

Novel hematopoietic stem cell engineering and transplantation approaches for HIV cure

goldLicense: CC BY NC ND

publisherhttps://api.elsevier.com/content/article/PII:S2329050123001080?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2329050123001080?httpAccept=text/plain

Europe_PMChttps://europepmc.org/articles/PMC10415663

Europe_PMChttps://europepmc.org/articles/PMC10415663?pdf=render

https://doi.org/10.1016/j.omtm.2023.07.006

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

Gene therapyHematopoietic stem cellsCell therapyConditioningAutologous TransplantCrisprNonhuman PrimateMedical BiotechnologyImmunologyQH426-470Regenerative Medicine618Stem Cell Research - Nonembryonic - HumanGeneticsTransplantationBiomedical and Clinical SciencesQH573-671Stem Cell ResearchInfectious DiseasesGood Health and Well BeingHIV/AIDSSexually Transmitted InfectionsStem Cell Research - Nonembryonic - Non-HumanOriginal ArticleCytologyBiotechnology

Sustainable Development Goals

SDG 3: 3. Good health