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Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM

Progress in Biophysics and Molecular Biology(2020)10.1016/j.pbiomolbio.2020.09.003Source: DataRank Database

Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM is a research paper published in Progress in Biophysics and Molecular Biology (2020). On theSindex it has a DataRank of 0. It has been cited 20 times.

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Enrichment:Funding (8 grants)OA: hybridTopics (49)IDs (PubMed, PMC)Annotations (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Daniel J. Rosenberg ORCID,Jan C. Bierma ORCID,Gregory L. Hura,Roopa Thapar ORCID,Susan P. Lees‐Miller ORCID

Live enrichment

PubMed:32966823 PMC:PMC8896507

NIGMS NIH HHS

Grant: P30 GM124169

NCI NIH HHS

Grant: R35 CA220430

NCI NIH HHS

Grant: P01 CA092584

National Institutes of Health

Grant: 2P30GM124169-06

ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)

National Institutes of Health

Grant: 3P01CA092584-19S1

Structural Cell Biology of DNA Repair Machines

National Institutes of Health

Grant: 5R35CA220430-02

Mesocale And Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC)

U.S. Department of Energy

National Institutes of Health

hybridLicense: cc-by-nc-nd

publisherhttps://www.sciencedirect.com/science/article/pii/S0079610720300912/pdf

repositoryhttps://escholarship.org/uc/item/9kv9z79k

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8896507

repositoryhttps://www.osti.gov/biblio/1769492

repositoryhttps://www.osti.gov/biblio/1813417

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

HoloenzymesDNACryoelectron MicroscopyX-Ray DiffractionDNA RepairDNA-Activated Protein KinaseScattering, Small AngleKu Autoantigen

Keywords

X-ray scatteringCryo-electron microscopyGenome StabilityStructural DynamicsDna Break RepairSmall Angle570DNA Repair1.1 Normal biological development and functioningBiophysics0601 Biochemistry and Cell Biology (for)610DNA-Activated Protein KinaseScatteringX-Ray Diffraction (mesh)X-Ray DiffractionScattering, Small AngleGeneticsDNA Repair (mesh)3101 Biochemistry and cell biology (for-2020)Ku AutoantigenSmall Angle (mesh)Cryoelectron Microscopy (mesh)1.1 Normal biological development and functioning (hrcs-rac)31 Biological Sciences (for-2020)Genetics (rcdc)Generic health relevance (hrcs-hc)Cryoelectron MicroscopyKu Autoantigen (mesh)DNABiological SciencesDNA-Activated Protein Kinase (mesh)Biochemistry and Cell BiologyGeneric health relevanceDNA (mesh)Biophysics (science-metrix)HoloenzymesHoloenzymes (mesh)